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Research ArticleBrain

Widespread Microstructural White Matter Involvement in Amyotrophic Lateral Sclerosis: A Whole-Brain DTI Study

M. Cirillo, F. Esposito, G. Tedeschi, G. Caiazzo, A. Sagnelli, G. Piccirillo, R. Conforti, F. Tortora, M.R. Monsurrò, S. Cirillo and F. Trojsi
American Journal of Neuroradiology June 2012, 33 (6) 1102-1108; DOI: https://doi.org/10.3174/ajnr.A2918
M. Cirillo
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F. Esposito
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G. Tedeschi
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G. Caiazzo
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A. Sagnelli
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G. Piccirillo
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R. Conforti
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F. Tortora
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M.R. Monsurrò
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S. Cirillo
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F. Trojsi
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References

  1. 1.↵
    1. Davidoff RA
    . The pyramidal tract. Neurology 1990;40:332–39
    FREE Full Text
  2. 2.↵
    1. Ellis CM,
    2. Simmons A,
    3. Jones DK,
    4. et al
    . Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology 1999;53:1051–58
    Abstract/FREE Full Text
  3. 3.↵
    1. Basser PJ,
    2. Pierpaoli C
    . Microstructural and physiological features of tissues elucidated by quantitative-diffusion tensor MRI. J Magn Reson 1996;111:209–19
    CrossRefWeb of Science
  4. 4.↵
    1. Toosy AT,
    2. Werring DJ,
    3. Orrell RW,
    4. et al
    . Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2003;74:1250–57
    Abstract/FREE Full Text
  5. 5.↵
    1. Graham JM,
    2. Papadakis N,
    3. Evans J,
    4. et al
    . Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS. Neurology 2004;63:2111–19
    Abstract/FREE Full Text
  6. 6.↵
    1. Sach M,
    2. Winkler G,
    3. Glauche V,
    4. et al
    . Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain 2004;127:340–50
    Abstract/FREE Full Text
  7. 7.↵
    1. Iwata NK,
    2. Aoki S,
    3. Okabe S,
    4. et al
    . Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation. Neurology 2008;70:528–32
    Abstract/FREE Full Text
  8. 8.↵
    1. Metwalli NS,
    2. Benatar M,
    3. Nair G,
    4. et al
    . Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis. Brain Res 2010;1348:156–64
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Agosta F,
    2. Pagani E,
    3. Petrolini M,
    4. et al
    . Assessment of white matter tract damage in patients with amyotrophic lateral sclerosis: a diffusion tensor MR imaging tractography study. AJNR Am J Neuroradiol 2010;31:1457–61
    Abstract/FREE Full Text
  10. 10.↵
    1. Ciccarelli O,
    2. Behrens TE,
    3. Altmann DR,
    4. et al
    . Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis. Brain 2006;129:1859–71
    Abstract/FREE Full Text
  11. 11.↵
    1. Sage CA,
    2. Peeters RR,
    3. Gorner A,
    4. et al
    . Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage 2007;34:486–99
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Thivard L,
    2. Pradat PF,
    3. Lehéricy S,
    4. et al
    . Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability. J Neurol Neurosurg Psychiatry 2007;78:889–92
    Abstract/FREE Full Text
  13. 13.↵
    1. Geser F,
    2. Martinez-Lage M,
    3. Robinson J,
    4. et al
    . Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol 2009;66:180–89
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Abe O,
    2. Yamada H,
    3. Masutani Y,
    4. et al
    . Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis. NMR Biomed 2004;17:411–16
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Agosta F,
    2. Pagani E,
    3. Rocca MA,
    4. et al
    . Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability. Hum Brain Mapp 2007;28:1430–38
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Johansen-Berg H,
    4. et al
    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–505
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Sage CA,
    2. Van Hecke W,
    3. Peeters R,
    4. et al
    . Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited. Hum Brain Mapp 2009;30:3657–75
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Ciccarelli O,
    2. Behrens TE,
    3. Johansen-Berg H,
    4. et al
    . Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics. Hum Brain Mapp 2009;30:615–24
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Filippini N,
    2. Douaud G,
    3. Mackay CE,
    4. et al
    . Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology 2010;75:1645–52
    Abstract/FREE Full Text
  20. 20.↵
    1. Senda J,
    2. Kato S,
    3. Kaga T,
    4. et al
    . Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study. Amyotroph Lateral Scler 2011;12:59–69
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Hua K,
    2. Zhang J,
    3. Wakana S,
    4. et al
    . Tract probability maps in stereotaxic spaces: analysis of white matter anatomy and tract-specific quantification. Neuroimage 2008;39:336–47
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Wakana S,
    2. Caprihan A,
    3. Panzenboeck MM,
    4. et al
    . Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 2007;36:630–44
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Brooks BR,
    2. Miller RG,
    3. Swash M,
    4. et al
    . El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1:293–99
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Cedarbaum JM,
    2. Stambler N,
    3. Malta E,
    4. et al
    . The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function: BDNF ALS Study Group (Phase III). J Neurol Sci 1999;169:13–21
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Kaufmann P,
    2. Pullman SL,
    3. Shungu DC,
    4. et al
    . Objective tests for upper motor neuron involvement in amyotrophic lateral sclerosis (ALS). Neurology 2004;62:1753–57
    Abstract/FREE Full Text
  26. 26.↵
    1. Grace J,
    2. Stout JC,
    3. Malloy PF
    . Assessing frontal lobe behavioral syndromes with the frontal lobe personality scale. Assessment 1999;6:269–84
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Nishihira Y,
    2. Tan CF,
    3. Toyoshima Y,
    4. et al
    . Sporadic amyotrophic lateral sclerosis: widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator. Neuropathology 2009;29:689–96
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Nishihira Y,
    2. Tan CF,
    3. Onodera O,
    4. et al
    . Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions. Acta Neuropathol 2008;116:169–82
    CrossRefPubMed
  29. 29.↵
    1. Eisen AA,
    2. Shaw PJ
    1. Ince PG,
    2. Wharton SB
    . Cytopathology of the motor neuron. In: Eisen AA, Shaw PJ eds. Motor Neuron Disorders and Related Diseases: Handbook of Clinical Neurology. 3rd Series. Amsterdam, the Netherlands: Elsevier; 2007:89–119
  30. 30.↵
    1. Clement AM,
    2. Nguyen MD,
    3. Roberts EA,
    4. et al
    . Wildtype non-neuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003;302:113–17
    Abstract/FREE Full Text
  31. 31.↵
    1. Chang JL,
    2. Lomen-Hoerth C,
    3. Murphy J,
    4. et al
    . A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. Neurology 2005;65:75–80
    Abstract/FREE Full Text
  32. 32.↵
    1. De Stefano N,
    2. Iannucci G,
    3. Sormani MP,
    4. et al
    . MR correlates of cerebral atrophy in patients with multiple sclerosis. J Neurol 2002;249:1072–77
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Brownell B,
    2. Oppenheimer DR,
    3. Hughes JT
    . The central nervous system in motor neuron disease. J Neurol Neurosurg Psychiatry 1970;33:338–57
    Abstract/FREE Full Text
  34. 34.↵
    1. Smith MC
    . Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1960;23:269–82
    FREE Full Text
  35. 35.↵
    1. Chao YP,
    2. Cho KH,
    3. Yeh CH,
    4. et al
    . Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and high angular resolution diffusion imaging tractography. Hum Brain Mapp 2009;30:3172–87
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Matsuoka T,
    2. Fujii N,
    3. Kondo A,
    4. et al
    . An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions. Neuropathology 2011;31:71–76
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Tedeschi G,
    2. Trojsi F,
    3. Tessitore A,
    4. et al
    . Interaction between aging and neurodegeneration in amyotrophic lateral sclerosis. Neurobiol Aging 2012;33:886–98
    CrossRefPubMed
  38. 38.↵
    1. Song SK,
    2. Sun SW,
    3. Ramsbottom MJ,
    4. et al
    . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Song SK,
    2. Yoshino J,
    3. Le TQ,
    4. et al
    . Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26:132–40
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Sullivan EV,
    2. Rohlfing T,
    3. Pfefferbaum A
    . Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance. Neurobiol Aging 2010;31:464–81
    CrossRefPubMedWeb of Science
  41. 41.↵
    1. Pfefferbaum A,
    2. Adalsteinsson E,
    3. Sullivan EV
    . Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol Aging 2006;27:994–1009
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Turner MR,
    2. Wicks P,
    3. Brownstein CA,
    4. et al
    . Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2011;82:853–54
    Abstract/FREE Full Text
  43. 43.↵
    1. Hatazawa J,
    2. Brooks RA,
    3. Dalakas MC,
    4. et al
    . Cortical motor-sensory hypometabolism in amyotrophic lateral sclerosis: a PET study. J Comput Assist Tomogr 1988;12:630–36
    PubMedWeb of Science
  44. 44.↵
    1. Rule RR,
    2. Schuff N,
    3. Miller RG,
    4. et al
    . Gray matter perfusion correlates with disease severity in ALS. Neurology 2010;74:821–27
    Abstract/FREE Full Text
  45. 45.↵
    1. Swash M,
    2. Scholtz CL,
    3. Vowles G,
    4. et al
    . Selective and asymmetric vulnerability of corticospinal and spinocerebellar tracts in motor neuron disease. J Neurol Neurosurg Psychiatry 1988;51:785–89
    Abstract/FREE Full Text
  46. 46.↵
    1. Wang S,
    2. Poptani H,
    3. Woo JH,
    4. et al
    . Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T. Radiology 2006;239:831–38. Epub 2006 Apr 26
    CrossRefPubMedWeb of Science
  47. 47.↵
    1. Murphy J,
    2. Henry R,
    3. Lomen-Hoerth C
    . Establishing subtypes of the continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol 2007;64:330–34
    CrossRefPubMedWeb of Science
  48. 48.↵
    1. Abrahams S,
    2. Goldstein LH,
    3. Suckling J,
    4. et al
    . Frontotemporal white matter changes in amyotrophic lateral sclerosis. J Neurol 2005;252:321–31
    CrossRefPubMedWeb of Science
  49. 49.↵
    1. Whitwell JL,
    2. Avula R,
    3. Senjem ML,
    4. et al
    . Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology 2010;74:1279–87
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 33 (6)
American Journal of Neuroradiology
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M. Cirillo, F. Esposito, G. Tedeschi, G. Caiazzo, A. Sagnelli, G. Piccirillo, R. Conforti, F. Tortora, M.R. Monsurrò, S. Cirillo, F. Trojsi
Widespread Microstructural White Matter Involvement in Amyotrophic Lateral Sclerosis: A Whole-Brain DTI Study
American Journal of Neuroradiology Jun 2012, 33 (6) 1102-1108; DOI: 10.3174/ajnr.A2918

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Widespread Microstructural White Matter Involvement in Amyotrophic Lateral Sclerosis: A Whole-Brain DTI Study
M. Cirillo, F. Esposito, G. Tedeschi, G. Caiazzo, A. Sagnelli, G. Piccirillo, R. Conforti, F. Tortora, M.R. Monsurrò, S. Cirillo, F. Trojsi
American Journal of Neuroradiology Jun 2012, 33 (6) 1102-1108; DOI: 10.3174/ajnr.A2918
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