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Research ArticleBrain

Imaging Characteristics of Oligodendrogliomas That Predict Grade

L. Khalid, M. Carone, N. Dumrongpisutikul, J. Intrapiromkul, D. Bonekamp, P.B. Barker and D.M. Yousem
American Journal of Neuroradiology May 2012, 33 (5) 852-857; DOI: https://doi.org/10.3174/ajnr.A2895
L. Khalid
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M. Carone
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N. Dumrongpisutikul
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J. Intrapiromkul
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D. Bonekamp
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P.B. Barker
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D.M. Yousem
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  • Fig 1.
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    Fig 1.

    Grade II oligodendroglioma. A, Axial T2-weighted fast SE image shows a high-signal-intensity mass in left frontal lobe. B, Axial contrast-enhanced T1-weighted image shows no postcontrast enhancement within the left frontal lobe mass. C, Axial automated postprocessed ADC map yields a minimal ADC value of 946 × 10−6 mm2/s, above the 925 × 10−6 mm2/s threshold.

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    Fig 2.

    Grade III oligodendroglioma. A, Axial T2-weighted fast SE image shows a high-signal-intensity mass in left medial frontal and parietal lobes. B, Axial contrast-enhanced T1-weighted image shows minimal nodular post–contrast enhancement within the medial margin of the mass. C, Axial automated postprocessed ADC map shows low signal intensity along the posterior margin. D, As stated in “Materials and Methods,” 4 ROIs are placed in the areas visually assessed as the lowest in signal intensity on the ADC map. In this case, of the 4 ROIs, the lowest ADC value is 762 × 10−6 mm2/s, which was recorded for this grade III oligodendroglioma, below the 925 × 10−6 mm2/s threshold.

Tables

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    Table 1:

    Number of cases and their enhancement characteristics

    ScoreDegree of EnhancementNo. of Cases
    1No enhancement45
    2Minimal enhancement17
    3Moderate enhancement8
    4Severe enhancement5
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    Table 2:

    Contrast enhancement in oligodendrogliomas

    Tumor GradeEnhancingNonenhancing
    III218
    II937
    Total3045
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    Table 3:

    Performance of 17 multivariate prediction rulesa

    Predict Grade III If and Only IfSpecificitySensitivityNegative Predictive ValuePositive Predictive ValueAccuracySpecificity + Sensitivity
    A89.1%62.1%78.9%78.3%78.7%151.2%
    E80.4%72.4%82.2%70.0%77.3%152.9%
    C75.0%52.4%64.3%64.7%64.4%127.4%
    A + E95.7%41.4%72.1%85.7%74.7%137.0%
    A + C91.7%38.1%62.9%80.0%66.7%129.8%
    E + C87.5%52.4%67.7%78.6%71.1%139.9%
    A or E73.9%93.1%94.4%69.2%81.3%167.0%
    A or C75.0%81.0%81.8%73.9%77.8%156.0%
    E or C66.7%76.2%76.2%66.7%71.1%142.9%
    A + E + C95.8%38.1%63.9%88.9%68.9%133.9%
    A or E or C66.7%95.2%94.1%71.4%80.0%161.9%
    A or (E + C)83.3%81.0%83.3%81.0%82.2%164.3%
    E or (A + C)75.0%76.2%78.3%72.7%75.6%151.2%
    C or (A + E)75.0%61.9%69.2%68.4%68.9%136.9%
    A + (E or C)91.7%47.6%66.7%83.3%71.1%139.3%
    E + (A or C)87.5%61.9%72.4%81.3%75.6%149.4%
    C + (A or E)83.3%52.4%66.7%73.3%68.9%135.7%
    • ↵a Based on the dichotomizations of ADC (A), enhancement (E), and calcification (C).

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American Journal of Neuroradiology: 33 (5)
American Journal of Neuroradiology
Vol. 33, Issue 5
1 May 2012
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L. Khalid, M. Carone, N. Dumrongpisutikul, J. Intrapiromkul, D. Bonekamp, P.B. Barker, D.M. Yousem
Imaging Characteristics of Oligodendrogliomas That Predict Grade
American Journal of Neuroradiology May 2012, 33 (5) 852-857; DOI: 10.3174/ajnr.A2895

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Imaging Characteristics of Oligodendrogliomas That Predict Grade
L. Khalid, M. Carone, N. Dumrongpisutikul, J. Intrapiromkul, D. Bonekamp, P.B. Barker, D.M. Yousem
American Journal of Neuroradiology May 2012, 33 (5) 852-857; DOI: 10.3174/ajnr.A2895
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