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Research ArticleNeurointervention

Improved Arterial Visualization in Cerebral CT Perfusion–Derived Arteriograms Compared with Standard CT Angiography: A Visual Assessment Study

A.M. Mendrik, E.P.A. Vonken, G.A.P. de Kort, B. van Ginneken, E.J. Smit, M.A. Viergever and M. Prokop
American Journal of Neuroradiology December 2012, 33 (11) 2171-2177; DOI: https://doi.org/10.3174/ajnr.A3118
A.M. Mendrik
aFrom the Image Sciences Institute (A.M.M., B.v.G., M.A.V.)
cBiomedical Imaging Group Rotterdam (A.M.M.), Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands
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E.P.A. Vonken
bRadiology Department (E.P.A.V., G.A.P.d.K., E.J.S., M.P.), University Medical Center Utrecht, Utrecht, the Netherlands
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G.A.P. de Kort
bRadiology Department (E.P.A.V., G.A.P.d.K., E.J.S., M.P.), University Medical Center Utrecht, Utrecht, the Netherlands
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B. van Ginneken
aFrom the Image Sciences Institute (A.M.M., B.v.G., M.A.V.)
dRadboud University Nijmegen Medical Centre (B.v.G., M.P.), Nijmegen, the Netherlands
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E.J. Smit
bRadiology Department (E.P.A.V., G.A.P.d.K., E.J.S., M.P.), University Medical Center Utrecht, Utrecht, the Netherlands
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M.A. Viergever
aFrom the Image Sciences Institute (A.M.M., B.v.G., M.A.V.)
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M. Prokop
bRadiology Department (E.P.A.V., G.A.P.d.K., E.J.S., M.P.), University Medical Center Utrecht, Utrecht, the Netherlands
dRadboud University Nijmegen Medical Centre (B.v.G., M.P.), Nijmegen, the Netherlands
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  • Fig 1.
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    Fig 1.

    Schematic representation of the automatic algorithm to derive arteriograms (CTPa) from CT perfusion data described in Mendrik et al.9

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    Fig 2.

    Maximum intensity projections (20 mm) of 2 cases from the evaluation dataset in which the proximal arterial quality in the CTPa was considered equivalent to standard CTA by both observers. Left: Standard CT angiogram. Middle: CTP-derived angiogram showing both arteries and veins. Right: CTPa showing the arteries. Case 7: window = 870 HU, level = 340 HU. Case 21: window = 540 HU, level = 270 HU. Arrows indicate superimposed veins in CTA that are absent in CTPa.

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    Fig 3.

    Maximum intensity projections (30 mm; window, 780 HU; level, 400 HU) of case 2, which received low VAS scores for arterial quality in CTPa from both observers. The right medial cerebral artery is occluded; the small collateral arteries have a time-to-peak of the contrast enhancement curve similar to that of the veins and thus are not present in the CTP-derived arteriogram (arrow). On the CTP-derived angiogram, however, the collateral arteries are visible (arrow). The source of subarachnoid hemorrhage in this patient is thought to have been the earlier infarction that was caused by the right media occlusion.

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    Fig 4.

    Maximum intensity projection (20 mm) subimages of 4 different patients from the evaluation dataset with a window of 800 HU and a level of 350 HU. Two patients with subarachnoid blood (cases 11 and 20) and 2 with large aneurysms (cases 3 and 14) near the skull base, illustrating a clear arterial view due to the absence of bone, veins, and subarachnoid hemorrhage in CTPa. Top row: Standard CTA scans. Middle row: CTPa. Bottom row: Angiograms (showing both arteries and veins) derived from the CTP scans.

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    Table 1:

    Mean VAS scores of both observers, per arterial territory over 24 patients, for arterial visual quality in CTPa using standard CTA as a referencea

    Mean VAS Score Observer 1Mean VAS Score Observer 2
    Proximal arteries
        ACA territory94%95%
        MCAb territories93%94%
        PCA territory94%95%
    More peripheral arteries
        ACA territory87%90%
        MCAb territories81%91%
        PCA territory86%91%
    • ↵a A 100% score indicates fully equal to standard CTA.

    • ↵b Average over left and right sides.

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    Table 2:

    Mean VAS scores of both observers, per arterial territory over 24 patients, for the presence of superimposed bone and veins in CTPa using standard CTA as a referencea

    No. of Cases with Superimposed Bone in Standard CTAbPresence of Superimposed Bone in CTPaNo. of Cases with Superimposed Veins in Standard CTAcPresence of Superimposed Veins in CTPa
    Av Obs 1Av Obs 2Av Obs 1Av Obs 2
    Proximal area
        ACA territory125 %5 %184 %4 %
        MCAd territories45 %3 %236 %11 %
        PCA territory233 %3 %244 %9 %
    More peripheral area
        ACA territory23 %3 %225 %16 %
        MCAd territories85 %2 %247 %20 %
        PCA territory0––245 %20 %
    • Note:—Av indicates average; Obs, observer.

    • ↵a A 0% score indicates no presence of superimposed bone and veins in CTPa compared with the full presence in standard CTA.

    • ↵b Number of cases (of 24) in which bony structures hampered evaluation of arteries within the specific territory on standard CTA.

    • ↵c Number of cases (of 24) in which veins hampered evaluation of arteries within the specific territory on standard CTA.

    • ↵d Average over left and right sides.

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American Journal of Neuroradiology: 33 (11)
American Journal of Neuroradiology
Vol. 33, Issue 11
1 Dec 2012
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A.M. Mendrik, E.P.A. Vonken, G.A.P. de Kort, B. van Ginneken, E.J. Smit, M.A. Viergever, M. Prokop
Improved Arterial Visualization in Cerebral CT Perfusion–Derived Arteriograms Compared with Standard CT Angiography: A Visual Assessment Study
American Journal of Neuroradiology Dec 2012, 33 (11) 2171-2177; DOI: 10.3174/ajnr.A3118

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Improved Arterial Visualization in Cerebral CT Perfusion–Derived Arteriograms Compared with Standard CT Angiography: A Visual Assessment Study
A.M. Mendrik, E.P.A. Vonken, G.A.P. de Kort, B. van Ginneken, E.J. Smit, M.A. Viergever, M. Prokop
American Journal of Neuroradiology Dec 2012, 33 (11) 2171-2177; DOI: 10.3174/ajnr.A3118
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