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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Cerebral CT Perfusion Using an Interventional C-Arm Imaging System: Cerebral Blood Flow Measurements

A. Ganguly, A. Fieselmann, M. Marks, J. Rosenberg, J. Boese, Y. Deuerling-Zheng, M. Straka, G. Zaharchuk, R. Bammer and R. Fahrig
American Journal of Neuroradiology September 2011, 32 (8) 1525-1531; DOI: https://doi.org/10.3174/ajnr.A2518
A. Ganguly
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A. Fieselmann
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M. Marks
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J. Rosenberg
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J. Boese
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Y. Deuerling-Zheng
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M. Straka
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G. Zaharchuk
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R. Bammer
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R. Fahrig
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    Fig 1.

    Temporal spacing of different scan sets to allow higher temporal sampling. The function is a typical TDC extracted at 1-voxel position within a vessel, and the markers define the center time point of each rotation of the C-arm.

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    Fig 2.

    CBF maps for 6-scan sets (A-B-C-D-E-F) from different injection-protocol C-arm CBCT (A−C) and CTP images (D−F). The 3 injection protocols used are 3 mL/s 67% (A and D), 6 mL/s 50% (B and E), and 3 mL/s 100% (C and F). All injections had a duration of 8 seconds.

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    Fig 3.

    Results of CBF values for the 6-mL/s 50% contrast injection. (A), CTP, C-arm CBCT for scan sets (B), A-B-C-D-E-F (C), B-D-F (D), A-C (E), B-D and (F) B.

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    Fig 4.

    Bland-Altman plots of C-arm CBCT versus CT CBF values for the 3 different injection protocols. Units for both axes are milliliters/100 g/min of tissue. Filled gray circles represent average values in gray matter regions of interest; open circles, white matter regions of interest.

Tables

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    Table 1:

    Difference in CBF between right and left hemispheres calculated from the clinical CT images only, for ROIs located in located in grey or white matter in the 2 hemispheresa

    Injection MethodDifference in CBF between Left and Right Hemispheres (mL/100 g/min)
    White MatterGrey Matter
    6 mL/s 50%
        Mean2.041.98
        SD6.036.77
        Overall ρ0.92
        Overall r0.92
    3 mL/s 100%
        Mean0.750.26
        SD7.869.49
        Overall ρ0.84
        Overall r0.84
    3 mL/s 67%
        Mean0.730.61
        SD9.246.74
        Overall ρ0.90
        Overall r0.90
    • a Mean and SD values are given in milliliters/100 g/min. The overall CCCs and the Pearson correlation coefficients between the left and right hemispheres (without grey/white matter discrimination) are also included and were found to be identical, implying no underlying bias due to position of the catheter or otherwise.

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    Table 2:

    Statistical results comparing the CBF values from CT and CBCT from different scan sets for the 6-mL/s 50% contrast-concentration injection protocola

    Scan SetCCC (ρ)Correlation Coefficient (r)Difference (CT-CBCT) (mL/100 g/min)Bland-Altman 95% Limits
    MeanSD
    B-D-F0.7960.876.568.34−9.78–22.89
    A-B-C-D-E-F0.7720.888.607.65−6.40–23.59
    A-C0.7510.888.787.68−6.27–23.84
    • a The top 3 candidates are shown.

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American Journal of Neuroradiology: 32 (8)
American Journal of Neuroradiology
Vol. 32, Issue 8
1 Sep 2011
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A. Ganguly, A. Fieselmann, M. Marks, J. Rosenberg, J. Boese, Y. Deuerling-Zheng, M. Straka, G. Zaharchuk, R. Bammer, R. Fahrig
Cerebral CT Perfusion Using an Interventional C-Arm Imaging System: Cerebral Blood Flow Measurements
American Journal of Neuroradiology Sep 2011, 32 (8) 1525-1531; DOI: 10.3174/ajnr.A2518

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Cerebral CT Perfusion Using an Interventional C-Arm Imaging System: Cerebral Blood Flow Measurements
A. Ganguly, A. Fieselmann, M. Marks, J. Rosenberg, J. Boese, Y. Deuerling-Zheng, M. Straka, G. Zaharchuk, R. Bammer, R. Fahrig
American Journal of Neuroradiology Sep 2011, 32 (8) 1525-1531; DOI: 10.3174/ajnr.A2518
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