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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctionalF
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Impact of Brain Tumor Location on Morbidity and Mortality: A Retrospective Functional MR Imaging Study

J.M. Wood, B. Kundu, A. Utter, T.A. Gallagher, J. Voss, V.A. Nair, J.S. Kuo, A.S. Field, C.H. Moritz, M.E. Meyerand and V. Prabhakaran
American Journal of Neuroradiology September 2011, 32 (8) 1420-1425; DOI: https://doi.org/10.3174/ajnr.A2679
J.M. Wood
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B. Kundu
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A. Utter
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T.A. Gallagher
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J. Voss
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V.A. Nair
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J.S. Kuo
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A.S. Field
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C.H. Moritz
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M.E. Meyerand
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V. Prabhakaran
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    Fig 1.

    Dissociation between motor and language deficits according to distance between tumor and eloquent cortex. The data suggest a linear relationship (R2=0.99) between distance from the tumor to the area of activation and the existence of motor deficits (red) and an asymptotic relationship (exponential fit, R2=0.88) between the distance from the tumor to the area of activation and the existence of language deficits (blue). Error bars depict 95% CIs calculated for a proportion.

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    Table 1:

    Demographics information

    Characteristics of Patients<1 cm1–2 cm>2 cmP Value
    Based on distance between lesion and SMC
        No. of subjects (n = 74)311627.09
        Male (%)555074.20
        Handedness (% right)a749376.34
        Mean age ± SD (yr)50 ± 17.043 ± 12.541 ± 15.5.05
        Grade III or IV tumors (%)715043.10
        Mean length of follow-up (mo)b403549.28
    Based on distance of lesion from Broca or Wernicke areac
        No. of subjects (n = 77)261536.01
        Male (%)614055.74
        Handedness (% right)817378.88
        Mean age ± SD (years)44 ± 14.440 ± 18.649 ± 15.7.12
        Grade III or IV tumors (%)546053.89
        Mean length of follow-up (mo)b585643.26
    • a For the motor deficits study cohort, handedness was unknown for n = 5 subjects.

    • b The survival analysis patient cohort is slightly different from the cohort used in other parameter characterizations.

    • c Grouping was based on minimum distance from either Broca or Wernicke area.

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    Table 2:

    Univariate analysis: relationship between patient characteristics and the existence of motor or language deficits

    CharacteristicNo DeficitsDeficitsP Value
    Motor
        Sex (% male)5765.63
        Age (mean)4150.02
        Handedness (% right)7776.99
        High-gradea4965.24
    Language
        Sex (% male)6060.86
        Age (mean)4350.04
        Handedness (% right)6990.05
        High-gradea4469.06
    • a High-grade tumors include grades III and IV on the WHO scale.

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    Table 3:

    Univariate analysis: relationship between LAD and the existence of language and motor deficits

    Characteristic<11–22+P Value
    SMC LAD vs motor deficits
        With pre- or postoperative paresis (%)84 (CI, 66–94)50 (CI, 28–72)11 (CI, 1–28)<.001
    Broca and/or Wernicke area LAD vs language deficits
        With pre- or postoperative aphasia (%)68 (CI, 48–83)33 (CI, 15–58)28 (CI, 16–44).009
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American Journal of Neuroradiology: 32 (8)
American Journal of Neuroradiology
Vol. 32, Issue 8
1 Sep 2011
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Cite this article
J.M. Wood, B. Kundu, A. Utter, T.A. Gallagher, J. Voss, V.A. Nair, J.S. Kuo, A.S. Field, C.H. Moritz, M.E. Meyerand, V. Prabhakaran
Impact of Brain Tumor Location on Morbidity and Mortality: A Retrospective Functional MR Imaging Study
American Journal of Neuroradiology Sep 2011, 32 (8) 1420-1425; DOI: 10.3174/ajnr.A2679

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Impact of Brain Tumor Location on Morbidity and Mortality: A Retrospective Functional MR Imaging Study
J.M. Wood, B. Kundu, A. Utter, T.A. Gallagher, J. Voss, V.A. Nair, J.S. Kuo, A.S. Field, C.H. Moritz, M.E. Meyerand, V. Prabhakaran
American Journal of Neuroradiology Sep 2011, 32 (8) 1420-1425; DOI: 10.3174/ajnr.A2679
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