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Research ArticleNeurointervention

Complex Bilobular, Bisaccular, and Broad-Neck Microsurgical Aneurysm Formation in the Rabbit Bifurcation Model for the Study of Upcoming Endovascular Techniques

S. Marbacher, S. Erhardt, J.-A. Schläppi, D. Coluccia, L. Remonda, J. Fandino and C. Sherif
American Journal of Neuroradiology April 2011, 32 (4) 772-777; DOI: https://doi.org/10.3174/ajnr.A2374
S. Marbacher
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S. Erhardt
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J.-A. Schläppi
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D. Coluccia
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L. Remonda
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J. Fandino
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C. Sherif
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  • Fig 1.
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    Fig 1.

    Schematic sketches of surgical steps, (A–C), intraoperative photographs under the operating microscope (A1–C1), and 2D-DSA (A2–C2) as well as CE-3D-MRA (A3–C3) screen shots of bilobular, bisaccular, and broad-neck aneurysms. A, Bilobular aneurysm. The jugular vein bifurcation stump is anastomosed to the CCA bifurcation, as described in the text and presented in Fig 3. B, Bisaccular aneurysm. Two venous pouches of the left or right external jugular vein are sutured together (white arrow) and anastomosed to the CCA bifurcation. C, Broad-based aneurysm. A 1-cm segment of the left external jugular vein is incised in a longitudinal manner, folded along its transverse axis (1), sutured together proximally (4–5 sutures) and distally (2–3 sutures) (2), and anastomosed to the CCA bifurcation (3).

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    Fig 2.

    Arterial (red, A) and venous (blue, B) neck vascular anatomy of the rabbit. A, The LCCA is exposed and isolated for a segment of at least 5 cm. The RCCA is dissected distally to its proximal origin at the brachiocephalic trunk (black circle) to achieve a tensionless end-to-side anastomosis of the RCCA to the LCCA (black arrow). B, A 10- to 15-mm segment of the right or left external jugular vein is used for the construction of bisaccluar and broad-neck aneurysms. The internal-external (asterisk) or transverse-external (double asterisks) jugular vein bifurcation serves as a graft for the creation of bilobular aneurysms.

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    Fig 3.

    Surgical steps of the conventional microsurgical saccular (berry-shaped) venous pouch bifurcation aneurysm model. A, Anastomosis sequences on the back side of the aneurysm (white arrows): 1) The LCCA is sutured to the RCCA. 2) The VP is sutured to the RCCA. 3) The VP is sutured to the LCCA. B, Anastomosis sequences on the front side of the aneurysm (black arrows): 4) The LCCA is sutured to the RCCA. 5) The VP is sutured to the RCCA. 6) The VP is sutured to the LCCA.

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    Fig 4.

    A, The screenshots illustrate 2D-DSA measurements, including parent vessels and aneurysm length, width, and neck in reference to an external sizing device (highlighted inset boxes). B, The same vessel and aneurysm characteristics are measured in CE-3D-MRA.

Tables

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    Table 1:

    Surgical characteristics, 2D-DSA, and CE-3D-MRA morphometric measurements

    Model/ModalityNo.Operation Time (min)No. of SuturesRCCA (mm)p-LCCA (mm)d-LCCA (mm)Neck Width (mm)Length/Width Lobule 1 (mm)Length/Width Lobule 2 (mm)Volume (mm3)
    BL-2DD1155213.55.7/3.85.1/3.8122.4
    BL-3DM1.92.22.33.65.2/3.85.4/3.9123.7
    BL-2DD2135274.58.2/3.65.6/3.4123.7
    BL-3DM2.82.62.54.47.3/3.85.7/3.2128.5
    BL-2DD3170224.37.3/3.57/3.9153.4
    BL-3DM2.83.22.84.57.1/3.87.3/3.9169.9
    BS-2DD41892848.4/3.99.5/3.5178.6
    BS-3DM2.42.42.23.98.3/3.48.9/3.6165.8
    BS-2DD5190312.93.13.55.48.5/48.8/4.9272.6
    BS-3DM3.13.43.55.38.6/4.38.9/4.5266.3
    BS-2DD6160285.28.5/5.28.2/4.9335
    BS-3DM2.72.92.65.38.6/5.38.3/4.6327.5
    BN-2DD7140262.83.22.75.95.6/8.1–/–199.4
    BN-3DM33.22.85.35.2/8.7184.7
    BN-2DD81853233.42.79.24.3/9.5–/–137.9
    BN-3DM33.62.88.94.7/10.4180.3
    BN-2DD9165272.32.42.17.24.8/8.3–/–150.1
    BN-3DM2.42.32.37.34.3/9.3235
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    Table 2:

    Summary of 2D-DSA and CE-3D-MRA volumes

    Model/ModalityNo.Mean Volume (mm3)
    BL-2DD1–3133.2 ± 17.5
    BL-3DM140.7 ± 25.4
    BS-2DD4–5262.1 ± 78.7
    BS-3DM253.2 ± 81.4
    BN-2DD6–9162.5.1 ± 32.6
    BN-3DM200 ± 30.4
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American Journal of Neuroradiology: 32 (4)
American Journal of Neuroradiology
Vol. 32, Issue 4
1 Apr 2011
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Cite this article
S. Marbacher, S. Erhardt, J.-A. Schläppi, D. Coluccia, L. Remonda, J. Fandino, C. Sherif
Complex Bilobular, Bisaccular, and Broad-Neck Microsurgical Aneurysm Formation in the Rabbit Bifurcation Model for the Study of Upcoming Endovascular Techniques
American Journal of Neuroradiology Apr 2011, 32 (4) 772-777; DOI: 10.3174/ajnr.A2374

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Complex Bilobular, Bisaccular, and Broad-Neck Microsurgical Aneurysm Formation in the Rabbit Bifurcation Model for the Study of Upcoming Endovascular Techniques
S. Marbacher, S. Erhardt, J.-A. Schläppi, D. Coluccia, L. Remonda, J. Fandino, C. Sherif
American Journal of Neuroradiology Apr 2011, 32 (4) 772-777; DOI: 10.3174/ajnr.A2374
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