Article Figures & Data
Figures
- Fig 1.
An example of how the regions of interest were determined in this patient with a glioblastoma. The upper panel shows the images from the image-guidance system, and the lower panel shows the SPGR image with the region of interest corresponding to this biopsy site (black box). The center of the region of interest is located at the biopsy site, and the orientation is in line with the biopsy tract.
- Fig 2.
Graph shows the correlation between mean rCBV values and the MIB-1 labeling index. There is a good correlation between these parameters—a finding that was mirrored by the other measures of rCBV.
- Fig 3.
Graph shows a lack of correlation between rCBV and cellular packing attenuation. The results shown here for mean rCBV are mirrored by the other measures of rCBV, except the rCBV90%, which showed a correlation.
- Fig 4.
An example of the perfusion imaging and photomicrographs of MIB-1 immunohistochemistry (×40) from 2 biopsy sites in a patient with a glioblastoma. A, A biopsy obtained at the center of the tumor. The rCBV mean is 8.1 and the MIB-1 labeling index is 33%. B, A second biopsy site was obtained 2 cm from the edge of the contrast-enhanced region. The mean rCBV is elevated at 2.3, and histology showed that the MIB-1 was 3.5% in this sparsely cellular region.
Tables
No. Age/ Sex WHO Grade Histology 1 42 M III Anaplastic astrocytoma 2 75 M IV Glioblastoma 3 60 M IV Glioblastoma 4 55 F IV Glioblastoma 5 32 M IV Glioblastoma 6 72 M IV Glioblastoma 7 79 M IV Glioblastoma 8 67 M IV Glioblastoma with oligodendroglial component 9 66 F IV Glioblastoma with oligodendroglial component 10 23 M IV PNET rCBV Measure Correlation Coefficient P Value rCBVmean 0.66 <.001 rCBVmax 0.56 <.001 rCBV75% 0.60 <.001 rCBV90% 0.58 <.001 - Table 3:
Correlation coefficients for different rCBV measures and cellular packing density
rCBV Measure Correlation Coefficient P Value rCBVmean 0.09 NS rCBVmax 0.29 NS rCBV75% 0.19 NS rCBV90% 0.36 .03
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