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Research ArticlePediatric Neuroimaging

Quantitative Diffusion-Weighted and Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Analysis of T2 Hypointense Lesion Components in Pediatric Diffuse Intrinsic Pontine Glioma

U. Löbel, J. Sedlacik, W.E. Reddick, M. Kocak, Q. Ji, A. Broniscer, C.M. Hillenbrand and Z. Patay
American Journal of Neuroradiology February 2011, 32 (2) 315-322; DOI: https://doi.org/10.3174/ajnr.A2277
U. Löbel
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J. Sedlacik
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W.E. Reddick
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M. Kocak
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Q. Ji
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A. Broniscer
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C.M. Hillenbrand
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Z. Patay
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  • Fig 1.
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    Fig 1.

    Regions of interest for T2HOF (1), T2HRT (2), WM (3), and GM (4) shown on the ADC map (left) and the T2*-weighted perfusion image before injection of contrast agent (right).

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    Fig 2.

    Signal-intensity curves of the tumor areas (T2HOF and T2HRT), the normal-appearing cerebellar WM and GM, and the AIF for a single patient. The markers indicate the actual values measured; the lines indicate the fit functions to the first pass of the contrast agent.

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    Fig 3.

    Appearance of T2HOF on conventional MR imaging and DWI for the 10 patients included in the evaluation of quantitative data. From left to right: T2-weighted, T1 subtraction image (or T1-weighted postcontrast image), diffusion trace image, and ADC map.

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    Fig 4.

    Results of diffusion imaging. A, ADC values of all lesions are significantly lower. B, FA values (not available for all patients) are significantly higher in T2HOF (y-axis) than in T2HRT (x-axis).

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    Fig 5.

    Results of perfusion imaging. A, rCBV values are significantly higher in T2HOF (y-axis) than in T2HRT (x-axis). B and C, No statistically significant difference is observed for (B) rCBF and (C) rMTT. Parameters were calculated relative to normal-appearing cerebellar GM.

Tables

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  • Summary of data obtained for 10 patients

    No.Age (yr)SexLesion CategoryADC (μm2/ms) (Median)FA (Median)rCBVrCBFMTTIndex Lesiona
    T2HOFT2HRTWMGMT2HOFT2HRTWMGMT2HOFT2HRTT2HOFT2HRTT2HOFT2HRT
    14.6M21.491.960.900.931.451.120.930.931.751.32x
    23.6F31.041.700.710.730.961.000.340.553.501.99x
    30.891.700.710.730.771.000.560.551.441.99
    31.2M21.362.130.800.870.270.160.580.230.590.571.110.630.490.88
    11.382.130.800.870.340.160.580.230.980.570.900.631.030.88x
    45.7M30.881.710.780.702.621.171.190.842.271.41x
    53.7F30.811.460.730.751.660.750.710.592.371.28x
    63.6F11.952.020.780.790.120.070.380.250.940.450.410.472.520.94x
    74.6M11.181.650.820.760.310.120.420.240.400.230.300.271.370.84x
    88.9F20.711.920.730.690.220.080.280.222.390.381.190.732.890.50x
    20.761.920.730.690.330.080.280.222.190.381.880.731.170.50
    913.1M21.041.360.740.750.210.240.420.292.071.571.490.551.454.43x
    109.4M21.021.530.710.880.210.120.510.251.051.251.321.640.780.74x
    • a Lesions marked with x are used for calculation of P values.

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American Journal of Neuroradiology: 32 (2)
American Journal of Neuroradiology
Vol. 32, Issue 2
1 Feb 2011
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U. Löbel, J. Sedlacik, W.E. Reddick, M. Kocak, Q. Ji, A. Broniscer, C.M. Hillenbrand, Z. Patay
Quantitative Diffusion-Weighted and Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Analysis of T2 Hypointense Lesion Components in Pediatric Diffuse Intrinsic Pontine Glioma
American Journal of Neuroradiology Feb 2011, 32 (2) 315-322; DOI: 10.3174/ajnr.A2277

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Quantitative Diffusion-Weighted and Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Analysis of T2 Hypointense Lesion Components in Pediatric Diffuse Intrinsic Pontine Glioma
U. Löbel, J. Sedlacik, W.E. Reddick, M. Kocak, Q. Ji, A. Broniscer, C.M. Hillenbrand, Z. Patay
American Journal of Neuroradiology Feb 2011, 32 (2) 315-322; DOI: 10.3174/ajnr.A2277
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  • MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma
  • Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium
  • Correlation of 18F-FDG PET and MRI Apparent Diffusion Coefficient Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium
  • MRI Evaluation of Non-Necrotic T2-Hyperintense Foci in Pediatric Diffuse Intrinsic Pontine Glioma
  • Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood
  • MR Imaging-Based Analysis of Glioblastoma Multiforme: Estimation of IDH1 Mutation Status
  • Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors
  • MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
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