Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials

I.J. van den Elskamp, D.L. Knol, B.M.J. Uitdehaag and F. Barkhof
American Journal of Neuroradiology December 2011, 32 (11) 2093-2097; DOI: https://doi.org/10.3174/ajnr.A2691
I.J. van den Elskamp
aFrom the Departments of Radiology (I.J.v.d.E., F.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.L. Knol
bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.M.J. Uitdehaag
bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)
cNeurology (B.M.J.U.), VU University Medical Center, Amsterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Barkhof
aFrom the Departments of Radiology (I.J.v.d.E., F.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Filippi M
    . Enhanced magnetic resonance imaging in multiple sclerosis. Mult Scler 2000;6:320–26
    Abstract/FREE Full Text
  2. 2.↵
    1. Di Rezze S,
    2. Gupta S,
    3. Durastanti V,
    4. et al
    . An exploratory study on interferon beta dose effect in reducing size of enhancing lesions in multiple sclerosis. Mult Scler 2007;13:343–47
    Abstract/FREE Full Text
  3. 3.↵
    1. Gupta S,
    2. Solomon JM,
    3. Tasciyan TA,
    4. et al
    . Interferon-beta-1b effects on re-enhancing lesions in patients with multiple sclerosis. Mult Scler 2005;11:658–68
    Abstract/FREE Full Text
  4. 4.↵
    1. Polman C,
    2. Barkhof F,
    3. Kappos L,
    4. et al.
    , the European Oral Interferon Beta-1a in Relapsing-Remitting MS Study Group. Oral interferon beta-1a in relapsing-remitting multiple sclerosis: a double-blind randomized study. Mult Scler 2003;9:342–48
    Abstract/FREE Full Text
  5. 5.↵
    1. Kappos L,
    2. Barkhof F,
    3. Desmet A
    . The effect of oral temsirolimus on new magnetic resonance imaging scan lesions, brain atrophy, and the number of relapses in multiple sclerosis: results from a randomised, controlled clinical trial. J Neurol 2005;252(suppl 2):46 (abstract 158)
    CrossRef
  6. 6.↵
    1. Miller DH,
    2. Albert PS,
    3. Barkhof F,
    4. et al
    . Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis: US National MS Society Task Force. Ann Neurol 1996;39:6–16
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Sormani MP,
    2. Filippi M
    . Statistical issues related to the use of MRI data in multiple sclerosis. J Neuroimaging 2007;17:56S–59S
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Lindsey JK
    . Models for Repeated Measurements. 2nd ed. Oxford, UK: Oxford University Press; 1999
  9. 9.↵
    1. Sormani MP,
    2. Miller DH,
    3. Comi G,
    4. et al
    . Clinical trials of multiple sclerosis monitored with enhanced MRI: new sample size calculations based on large data sets. J Neurol Neurosurg Psychiatry 2001;70:494–99
    Abstract/FREE Full Text
  10. 10.↵
    1. Sormani MP,
    2. Bruzzi P,
    3. Miller DH,
    4. et al
    . Modelling MRI enhancing lesion counts in multiple sclerosis using a negative binomial model: implications for clinical trials. J Neurol Sci 1999;163:74–80
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Comi G,
    2. Filippi M,
    3. Wolinsky JS
    . European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosis. Ann Neurol 2001;49:290–97
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Miller DH,
    2. Soon D,
    3. Fernando KT,
    4. et al
    . MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS. Neurology 2007;68:1390–401
    Abstract/FREE Full Text
  13. 13.↵
    1. Kappos L,
    2. Antel J,
    3. Comi G,
    4. et al
    . Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124–40
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. van den Elskamp IJ,
    2. Lembcke J,
    3. Dattola V,
    4. et al
    . Persistent T1 hypointensity as an MRI marker for treatment efficacy in multiple sclerosis. Mult Scler 2008;14:764–69
    Abstract/FREE Full Text
  15. 15.↵
    1. Li N,
    2. Elashoff DA,
    3. Robbins WA,
    4. et al
    . A hierarchical zero-inflated log-normal model for skewed responses. Stat Methods Med Res 2011;20:175–89
    Abstract/FREE Full Text
  16. 16.↵
    1. Dunn PK
    . Occurrence quantity of precipitation can be modeled simultaneously. Int J Climatology 2004;24:1231–39
    CrossRef
  17. 17.↵
    1. Shono H
    . Application of the Tweedie distribution to zero-catch data in CPUE analysis. Fisheries Research 2008;93:154–62
    CrossRefWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 32 (11)
American Journal of Neuroradiology
Vol. 32, Issue 11
1 Dec 2011
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
I.J. van den Elskamp, D.L. Knol, B.M.J. Uitdehaag, F. Barkhof
Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials
American Journal of Neuroradiology Dec 2011, 32 (11) 2093-2097; DOI: 10.3174/ajnr.A2691

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials
I.J. van den Elskamp, D.L. Knol, B.M.J. Uitdehaag, F. Barkhof
American Journal of Neuroradiology Dec 2011, 32 (11) 2093-2097; DOI: 10.3174/ajnr.A2691
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Right hemisphere structures predict poststroke speech fluency
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations
  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire