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Research ArticleBrain

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

M.F. Covington, S.S. Chin and A.G. Osborn
American Journal of Neuroradiology December 2011, 32 (11) 2067-2072; DOI: https://doi.org/10.3174/ajnr.A2717
M.F. Covington
cUniversity of Utah School of Medicine (M.F.C.), Salt Lake City, Utah.
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S.S. Chin
aFrom the Departments of Pathology (S.S.C.)
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A.G. Osborn
bRadiology (A.G.O.)
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  • Fig 1.
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    Fig 1.

    Pituicytoma. Sagittal T1WI image (A) and coronal T1WI postcontrast scan (B) show a rounded suprasellar mass that is clearly separate from the pituitary gland. (From Gibbs WN, Monuki ES, Linskey ME et al. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol 2006:27:1639–42. Used with permission.)

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    Fig 2.

    Spindle cell oncocytoma. Coronal T1WI (A) demonstrates a mixed intra- and suprasellar infiltrating pituitary lesion. Coronal T1-postcontrast scan (B) reveals a heterogeneous pattern of enhancement. Sagittal T1WI (C) shows enlargement of the anterior pituitary by the infiltrating mass and displacement of the unaffected neurohypophysis. (From Vajtai I, Sahli R, Kappeler A. Spindle cell oncocytoma of the adenohypophysis: report of a case with a 16-year follow-up. Pathol Res Pract 2006:202:745–50. Used with permission.)

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    Fig 3.

    Granular cell tumor. T1-weighted postcontrast scan (A) demonstrates a large suprasellar mass with a heterogeneous pattern of enhancement that is clearly separate from the pituitary gland. Contrast-enhanced axial CT (B) shows a large mass with heterogeneous enhancement that is hyperattenuated compared with brain. (From Buhl R, Hugo HH, Hempelmann RG et al. Granular-cell tumor: a rare suprasellar mass. Neuroradiology 2001:43:309–12. Used with permission.)

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    Fig 4.

    Key diagnostic considerations for pituicytoma, SCO, and GCT.

Tables

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    Table 1:

    Anatomic location for cases of pituicytoma, SCO, and GCT

    LocationPituicytomaSCOGCT
    Sellar7/330/130/45
    Sellar/suprasellar13/3313/1317/45
    Suprasellar13/330/1328/45
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    Table 2:

    MR signal characteristics for pituicytoma, SCO, and GCT

    T1WIn/TotalT2WIn/TotalEnhancementn/Total
    PituicytomaHypointense0/15Hypointense1/8Heterogeneous5/19
    Isointense13/15Isointense1/8Homogeneous14/19
    Hyperintense2/15Hyperintense6/8
    SCOHypointense1/4Hypointense0/0Heterogeneous5/7
    Isointense3/4Isointense0/0Homogeneous2/7
    Hyperintense0/4Hyperintense0/0
    GCTHypointense4/24Hypointense7/17Heterogeneous12/23
    Isointense18/24Isointense10/17Homogeneous11/23
    Hyperintense2/24Hyperintense0/17
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    Table 3:

    Presenting symptoms for pituicytoma, SCO, and GCT

    Pituicytoma (n = 35)No. CasesSCO (n = 13)No. CasesGCT (n = 64)No. Cases
    Visual disturbance18Visual disturbance8Visual disturbance41
    Headache16Panhypopituitarism5Headache21
    Fatigue8Headache4Amenorrhea12
    Decreased libido7Fatigue2Fatigue8
    Hypopituitarism6Weight loss2Memory loss7
    DI1DI0DI3
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American Journal of Neuroradiology: 32 (11)
American Journal of Neuroradiology
Vol. 32, Issue 11
1 Dec 2011
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M.F. Covington, S.S. Chin, A.G. Osborn
Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893
American Journal of Neuroradiology Dec 2011, 32 (11) 2067-2072; DOI: 10.3174/ajnr.A2717

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Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893
M.F. Covington, S.S. Chin, A.G. Osborn
American Journal of Neuroradiology Dec 2011, 32 (11) 2067-2072; DOI: 10.3174/ajnr.A2717
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