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Research ArticleBrain

Added Value of High-Resolution MR Imaging in the Diagnosis of Vertebral Artery Dissection

O. Naggara, F. Louillet, E. Touzé, D. Roy, X. Leclerc, J.-L. Mas, J.-P. Pruvo, J.-F. Meder and C. Oppenheim
American Journal of Neuroradiology October 2010, 31 (9) 1707-1712; DOI: https://doi.org/10.3174/ajnr.A2165
O. Naggara
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F. Louillet
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E. Touzé
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D. Roy
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X. Leclerc
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J.-L. Mas
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J.-P. Pruvo
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J.-F. Meder
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C. Oppenheim
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    Fig 1.

    Distinction between mural hematoma and perivertebral hypertrophic venous plexus on HR-MR imaging. Axial high-resolution fat-suppressed PDWI (A and E), fat-suppressed T2WI (B and F), T1WI (C and G), and TOF sequences (D and H). In case 1 (top row), crescentic high signal intensity of the vertebral wall, brighter than the signal intensity of the sternocleidomastoid muscle on all sequences (A−D), is associated with a low signal intensity of the intimal layer between the lumen and the crescentic hyperintense mural thickening on TOF (D, arrow), corresponding to a mural hematoma. In case 2 (bottom row), crescentic high signal intensity of the vertebral wall, brighter than muscle signal intensity on TOF, PDWI, and T2WI (E, F, and H), is isointense to the muscle on T1WI (G), without magnetic susceptibility artifacts (H), leading to the diagnosis of inflow enhancement of a hypertrophic venous structure.

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    Fig 2.

    Example of discordance between the standard approach and HR-MR imaging. Suspicion of traumatic right acute VA dissection in a 25-year-old woman with sudden neck pain and dizziness, without stroke. DUS findings were consistent with a right vertebral mural hematoma (not shown). A, On CE-MRA, note irregularity of the right V2 segment (arrow). B, On axial fat-suppressed cervical T1WI, note hyperintense crescentic thickening of the right VA, associated with a slight crescentic hyperintensity of the left VA (arrows). C, On axial high-resolution T1WI, obtained 24 hours later, the crescentic hyperintense mural thickening is no longer present, leading to the diagnosis of inflow enhancement of the hypertrophic venous structure. D, On 6-month follow-up CE-MRA, the lumen of the right VA remains unchanged (arrow).

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    Fig 3.

    Example of discordance between the standard approach and HR-MR imaging. Suspicion of spontaneous acute dissection in a 40-year-old woman with left neck pain and laterobulbar acute stroke. A, On CE-MRA, note occlusion of the right VA and stenosis (arrow) of the left V3 segment. B, On axial fat-suppressed cervical T1WI, note inconclusive crescentic hyperintense mural thickening of the left VA (arrow) and a hyperintense occluded lumen of the right V3 segment (double arrow). DUS did not demonstrate any mural hematoma (not shown). C, On axial high-resolution fat-suppressed T2WI, obtained 24 hours later, note crescentic hyperintense mural thickening (arrow). D, On 5-month follow-up CE-MRA, note clear improvement of the left V3 stenosis. This favors the diagnosis of VAD.

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    Fig 4.

    Example of discordance between the standard approach and HR-MR imaging. Suspicion of spontaneous acute dissection in a 47-year-old woman with postchiropractic right neck pain and transient dizziness, without stroke. Findings of DUS were inconclusive (not shown). B, On standard axial fat-suppressed cervical T1WI, note nonspecific hyperintense crescentic mural thickening of the right V3 segment (arrows). A and D, On CE-MRA, note stenosis (arrow, A) of the right V3 segment, which was partially resolved on 1-year follow-up CE-MRA (D, arrow). C, Coronal high-resolution T1WI, obtained 24 hours after CE-MRA, demonstrates a clear hyperintense crescentic mural thickening of the right V3 segment (arrow). This supports the diagnosis of VAD.

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    Table 1:

    Demographic and clinical data

    Demographic Data
    Patients35
    Age (yr, mean, range)41.5 ± 8.5 (25–56)
    Male14 (40%)
    Migraine14
    Diabetes1
    Smoking19
    Hypercholesterolemia4
    Elevated blood pressure2
    Clinical presentation
        Trauma15
        Vertebral manipulation3
        Headache22
        Neck pain33
        Dizziness21
        Horner syndrome3
        Diplopia7
        Cerebellar signs13
        NIHSS score (mean, range)1.1 ± 1.9 (0–9)
    Imaging
        Stroke on DWI14
        Onset-to-HR-MR imaging delay (day, mean, range)8.6 ± 6.0 (3–16)
        Clinical follow-up (month, mean, range)9.6 ± 3.6 (6–32)
        Imaging follow-up (month, mean, range)7.4 ± 6.3 (4–32)
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    Table 2:

    Comparison of neurologists' and HR-MR classifications

    Neurologists' ClassificationsTotal
    VADNo VAD
    HR-MR imaging classification
        VAD14418
        No VAD41317
    Total181735
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American Journal of Neuroradiology: 31 (9)
American Journal of Neuroradiology
Vol. 31, Issue 9
1 Oct 2010
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Cite this article
O. Naggara, F. Louillet, E. Touzé, D. Roy, X. Leclerc, J.-L. Mas, J.-P. Pruvo, J.-F. Meder, C. Oppenheim
Added Value of High-Resolution MR Imaging in the Diagnosis of Vertebral Artery Dissection
American Journal of Neuroradiology Oct 2010, 31 (9) 1707-1712; DOI: 10.3174/ajnr.A2165

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Added Value of High-Resolution MR Imaging in the Diagnosis of Vertebral Artery Dissection
O. Naggara, F. Louillet, E. Touzé, D. Roy, X. Leclerc, J.-L. Mas, J.-P. Pruvo, J.-F. Meder, C. Oppenheim
American Journal of Neuroradiology Oct 2010, 31 (9) 1707-1712; DOI: 10.3174/ajnr.A2165
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