Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging—Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme

S.J. Mills, C. Soh, C.J. Rose, S. Cheung, S. Zhao, G.J.M. Parker and A. Jackson
American Journal of Neuroradiology March 2010, 31 (3) 549-553; DOI: https://doi.org/10.3174/ajnr.A1844
S.J. Mills
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Soh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.J. Rose
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Cheung
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Zhao
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G.J.M. Parker
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Jackson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Alexander DC,
    2. Hubbard PL,
    3. Hall MG,
    4. et al
    . Orientationally invariant axon-size and density weighted MRI. In: Proceedings of the International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii. April 18-24, 2009
  2. 2.↵
    1. Sen PN,
    2. Basser PJ
    . A model for diffusion in white matter in the brain. Biophys J 2005;89:2927–38
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Tofts PS,
    2. Brix G,
    3. Buckley DL,
    4. et al
    . Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223–32
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Moffat BA,
    2. Chenevert TL,
    3. Lawrence TS,
    4. et al
    . Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci U S A 2005;102:5524–29
    Abstract/FREE Full Text
  5. 5.↵
    1. Chenevert TL,
    2. Stegman LD,
    3. Taylor JM,
    4. et al
    . Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. J Natl Cancer Inst 2000;92:2029–36
    Abstract/FREE Full Text
  6. 6.↵
    1. Bastin ME,
    2. Carpenter TK,
    3. Armitage PA,
    4. et al
    . Effects of dexamethasone on cerebral perfusion and water diffusion in patients with high-grade glioma. AJNR Am J Neuroradiol 2006;27:402–08
    Abstract/FREE Full Text
  7. 7.↵
    1. Bastin ME,
    2. Delgado M,
    3. Whittle IR,
    4. et al
    . The use of diffusion tensor imaging in quantifying the effect of dexamethasone on brain tumours. Neuroreport 1999;10:1385–91
    PubMed
  8. 8.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Kochi M,
    4. et al
    . Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 1999;9:53–60
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Kono K,
    2. Inoue Y,
    3. Nakayama K,
    4. et al
    . The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22:1081–88
    Abstract/FREE Full Text
  10. 10.↵
    1. Guo AC,
    2. Cummings TJ,
    3. Dash RC,
    4. et al
    . Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 2002;224:177–83
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Yang D,
    2. Korogi Y,
    3. Sugahara T,
    4. et al
    . Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI. Neuroradiology 2002;44:656–66
    CrossRefPubMed
  12. 12.↵
    1. Yamasaki F,
    2. Kurisu K,
    3. Satoh K,
    4. et al
    . Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 2005;235:985–91
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Lee EJ,
    2. Lee SK,
    3. Agid R,
    4. et al
    . Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient. AJNR Am J Neuroradiol 2008;29:1872–77
    Abstract/FREE Full Text
  14. 14.↵
    1. Ludemann L,
    2. Grieger W,
    3. Wurm R,
    4. et al
    . Quantitative measurement of leakage volume and permeability in gliomas, meningiomas and brain metastases with dynamic contrast-enhanced MRI. Magn Reson Imaging 2005;23:833–41
    CrossRefPubMed
  15. 15.↵
    1. Zhu XP,
    2. Li KL,
    3. Kamaly-Asl ID,
    4. et al
    . Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 2000;11:575–85
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Ludemann L,
    2. Grieger W,
    3. Wurm R,
    4. et al
    . Comparison of dynamic contrast-enhanced MRI with WHO tumor grading for gliomas. Eur Radiol 2001;11:1231–41
    CrossRefPubMed
  17. 17.↵
    1. Andersen C,
    2. Jensen FT
    . Differences in blood-tumour-barrier leakage of human intracranial tumours: quantitative monitoring of vasogenic oedema and its response to glucocorticoid treatment. Acta Neurochir (Wien) 1998;140:919–24
    CrossRefPubMed
  18. 18.↵
    1. Armitage PA,
    2. Schwindack C,
    3. Bastin ME,
    4. et al
    . Quantitative assessment of intracranial tumor response to dexamethasone using diffusion, perfusion and permeability magnetic resonance imaging. Magn Reson Imaging 2007;25:303–10
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. McMillan KM,
    2. Rogers BP,
    3. Koay CG,
    4. et al
    . An objective method for combining multi-parametric MRI datasets to characterize malignant tumors. Med Phys 2007;34:1053–61
    CrossRefPubMed
  20. 20.↵
    1. Fram EK,
    2. Herfkens RJ,
    3. Johnson GA,
    4. et al
    . Rapid calculation of T1 using variable flip angle gradient refocused imaging. Magn Reson Imaging 1987;5:201–08
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Tofts PS
    . Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 1997;7:91–101
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Parker GJ,
    2. Jackson A,
    3. Waterton JC,
    4. et al
    . Automated arterial input function extraction for T1-weighted DCE-MRI. In: Proceedings of the 11th Annual Meeting of International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada. July 10–16, 2003:Abstract No. 1264
  23. 23.↵
    1. Jiang H,
    2. van Zijl PC,
    3. Kim J,
    4. et al
    . DTIStudio: resource program for diffusion tensor computation and fiber bundle tracking. Comput Methods Programs Biomed 2006;81:106–16
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Jenkinson M,
    2. Smith S
    . A global optimisation method for robust affine registration of brain images. Med Image Anal 2001;5:143–56
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Yankeelov TE,
    2. Lepage M,
    3. Chakravarthy A,
    4. et al
    . Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging 2007;25:1–13
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Guo Y,
    2. Cai YQ,
    3. Cai ZL,
    4. et al
    . Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging. J Magn Reson Imaging 2002;16:172–78
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Kinoshita T,
    2. Yashiro N,
    3. Ihara N,
    4. et al
    . Diffusion-weighted half-Fourier single-shot turbo spin echo imaging in breast tumors: differentiation of invasive ductal carcinoma from fibroadenoma. J Comput Assist Tomogr 2002;26:1042–46
    CrossRefPubMed
  28. 28.↵
    1. Kuroki Y,
    2. Nasu K,
    3. Kuroki S,
    4. et al
    . Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value. Magn Reson Med Sci 2004;3:79–85
    CrossRefPubMed
  29. 29.↵
    1. Sinha S,
    2. Lucas-Quesada FA,
    3. Sinha U,
    4. et al
    . In vivo diffusion-weighted MRI of the breast: potential for lesion characterization. J Magn Reson Imaging 2002;15:693–704
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Woodhams R,
    2. Matsunaga K,
    3. Iwabuchi K,
    4. et al
    . Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension. J Comput Assist Tomogr 2005;29:644–49
    CrossRefPubMed
  31. 31.↵
    1. Woodhams R,
    2. Matsunaga K,
    3. Kan S,
    4. et al
    . ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci 2005;4:35–42
    CrossRefPubMed
  32. 32.↵
    1. Norris DG
    . The effects of microscopic tissue parameters on the diffusion weighted magnetic resonance imaging experiment. NMR Biomed 2001;14:77–93
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Le Bihan D,
    2. Breton E,
    3. Lallemand D,
    4. et al
    . MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401–07
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Brunberg JA,
    2. Chenevert TL,
    3. McKeever PE,
    4. et al
    . In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres. AJNR Am J Neuroradiol 1995;16:361–71
    Abstract/FREE Full Text
  35. 35.↵
    1. Sadeghi N,
    2. D'Haene N,
    3. Decaestecker C,
    4. et al
    . Apparent diffusion coefficient and cerebral blood volume in brain gliomas: relation to tumor cell density and tumor microvessel density based on stereotactic biopsies. AJNR Am J Neuroradiol 2008;29:476–82
    Abstract/FREE Full Text
  36. 36.↵
    1. Shellock FG,
    2. Spinazzi A
    . MRI safety update 2008. Part 1. MRI contrast agents and nephrogenic systemic fibrosis. AJR Am J Roentgenol 2008;191:1129–39
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Bellin MF,
    2. Van Der Molen AJ
    . Extracellular gadolinium-based contrast media: an overview. Eur J Radiol 2008;66:160–67
    CrossRefPubMed
  38. 38.↵
    1. van der Molen AJ,
    2. Bellin MF
    . Extracellular gadolinium-based contrast media: differences in diagnostic efficacy. Eur J Radiol 2008;66:168–74
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging—Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.J. Mills, C. Soh, C.J. Rose, S. Cheung, S. Zhao, G.J.M. Parker, A. Jackson
Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging—Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme
American Journal of Neuroradiology Mar 2010, 31 (3) 549-553; DOI: 10.3174/ajnr.A1844

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging—Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme
S.J. Mills, C. Soh, C.J. Rose, S. Cheung, S. Zhao, G.J.M. Parker, A. Jackson
American Journal of Neuroradiology Mar 2010, 31 (3) 549-553; DOI: 10.3174/ajnr.A1844
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade
  • Diagnostic Accuracy of T1-Weighted Dynamic Contrast-Enhanced-MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma
  • Automated Processing of Dynamic Contrast-Enhanced MRI: Correlation of Advanced Pharmacokinetic Metrics with Tumor Grade in Pediatric Brain Tumors
  • Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging
  • Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma
  • Potential Role of Preoperative Conventional MRI Including Diffusion Measurements in Assessing Epidermal Growth Factor Receptor Gene Amplification Status in Patients with Glioblastoma
  • Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study
  • Progression of Microstructural Damage in Spinocerebellar Ataxia Type 2: A Longitudinal DTI Study
  • Statin Therapy Does Not Affect the Radiographic and Clinical Profile of Patients with TIA and Minor Stroke
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire