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Research ArticleSpine Imaging and Spine Image-Guided InterventionsE

Nonenhancing Intramedullary Astrocytomas and Other MR Imaging Features: A Retrospective Study and Systematic Review

H.S. Seo, J.-h. Kim, D.H. Lee, Y.H. Lee, S.-i. Suh, S.Y. Kim and D.G. Na
American Journal of Neuroradiology March 2010, 31 (3) 498-503; DOI: https://doi.org/10.3174/ajnr.A1864
H.S. Seo
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J.-h. Kim
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D.H. Lee
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Y.H. Lee
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S.-i. Suh
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S.Y. Kim
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D.G. Na
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    Fig 1.

    A 50-year-old woman with nonenhancing WHO grade II diffuse astrocytoma. Her symptoms were progressive left-handed weakness, hypoesthesia, and lower right-legged paresthesia starting 5 months earlier. A and B, Axial and sagittal T2-weighted MR images show a well-demarcated hyperintense intramedullary mass at the cervical spinal cord. The mass is slightly eccentric to the left side from the spinal cord center on the axial image. There is no peritumoral edema, periapical cap, or hemorrhage. C and D, The mass is hypointense on axial and sagittal T1-weighted images. E and F, Contrast enhanced T1-weighted images show that the mass is not enhanced at all.

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    Fig 2.

    A 47-year-old woman with a nonenhancing WHO grade III anaplastic astrocytoma. Her chief symptoms were a left upper extremity tingling sense and weakness, which had gradually extended from the distal to the proximal portion. Thereafter, the same symptoms occurred in both lower extremities. A and B, Axial and sagittal T2-weighted MR images show an ill-defined slightly hyperintense mass at cervical spinal cord. C, The mass is isointense to the spinal cord on sagittal T1-weighted images. D and E, Contrast-enhanced axial and sagittal T1-weighted images show a nonenhanced mass.

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    Fig 3.

    A 19-year-old man with a nonenhancing WHO grade III anaplastic astrocytoma. His chief symptoms were left lower extremity weakness, hypoesthesia, and lower back pain starting 6 months earlier. A and B, Axial and sagittal T2-weighted MR images show a well-demarcated hyperintense mass at the center of the conus medullaris. C, The mass is hypointense on the sagittal T1-weighted image. D and E, Contrast-enhanced axial and sagittal T1-weighted images show that the mass is not enhanced at all.

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    Table 1:

    Contrast-enhancement patterns of intramedullary astrocytomas

    Enhancement PatternWHO GradeTotal (n = 19) (%)
    I (n = 3) (%)II (n = 13) (%)III (n = 3) (%)
    None0 (0)4 (31)2 (67)6 (32)
    Focal nodular1 (33)4 (31)0 (0)5 (26)
    Patchy1 (33)2 (15)0 (0)3 (16)
    Inhomogeneous diffuse1 (33)3 (23)1 (33)5 (26)
    Homogeneous diffuse0 (0)0 (0)0 (0)0 (0)
    • View popup
    Table 2:

    T1 MR imaging features of intramedullary astrocytomas

    T1 SignalCases (%)
    Hypointense11 (58)
    Isointense7 (37)
    Hyperintense1 (5)
    Axial Location
        Central13 (68)
        Eccentric6 (32)
    Other Findings
        Edema7 (37)
        Intratumoral cyst4 (21)
        Peritumoral cyst3 (16)
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    Table 3:

    T2 MR imaging features of intramedullary astrocytomas

    T2 SignalCases (%)
    Hyperintense18 (95)
    Isointense1 (5)
    Longitudinal Location
        Cervical10 (53)
        Thoracic5 (26)
        Cervical/thoracic2 (11)
        Thoracic/lumbar1 (5)
        Cervical/thoracic/lumbar1 (5)
    Other Findings
        Syrinx0 (0)
        Hemorrhage2 (11)
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    Table 4:

    Literature review

    StudyYearTotal No.No. Enhanced (%)Comment
    White et al.720073510 (29)Includes 2 nonenhancing anaplastic astrocytomas
    Lin and Zhang13200442 (50)
    Patel et al.111998151 (7)
    Breger et al.12198930 (0)
    Parizel et al.10198970 (0)Includes 1 pilocytic and 6 low-grade astrocytomas
    Dillon et al.9198960 (0)Includes 6 recurrent astrocytomas
    Sze et al.8198861 (17)Includes 4 primary and 2 recurrent astrocytomas
    Total7614 (18)
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American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
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Cite this article
H.S. Seo, J.-h. Kim, D.H. Lee, Y.H. Lee, S.-i. Suh, S.Y. Kim, D.G. Na
Nonenhancing Intramedullary Astrocytomas and Other MR Imaging Features: A Retrospective Study and Systematic Review
American Journal of Neuroradiology Mar 2010, 31 (3) 498-503; DOI: 10.3174/ajnr.A1864

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Nonenhancing Intramedullary Astrocytomas and Other MR Imaging Features: A Retrospective Study and Systematic Review
H.S. Seo, J.-h. Kim, D.H. Lee, Y.H. Lee, S.-i. Suh, S.Y. Kim, D.G. Na
American Journal of Neuroradiology Mar 2010, 31 (3) 498-503; DOI: 10.3174/ajnr.A1864
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