Article Figures & Data
Figures
- Fig 1.
Timing of different procedural steps in patients receiving and not receiving MOB infusion beyond the arterial occlusion. MOB allows intermittently advancing reperfusion for up to 2 hours before final recanalization is achieved.
- Fig 2.
M-mode and TCD recordings during the procedure. Note proximal left MCA occlusion and no detection of flow in the distal MCA branches between a 50- and 30-mm depth (asterisks). During the MOB perfusion beyond the clot, a nonpulsatile flow appears in the distal MCA branches (white arrows).
Tables
Patients characteristics according to treatment groupa
All Patients (n = 60) No MOB (n = 43) MOB (n = 17) P Value Age (yr) 72 (±11) 72.1 (±10.8) 71.9 (±11.2) .960 Female (%) 57.1 51.2 73.3 .142 Smoking (%) 14.9 15.6 13.3 .839 Hypertension (%) 66.7 71.4 53.8 .256 Diabetes (%) 18.4 19.4 15.4 .748 Atrial fibrillation (%) 60 58.3 64.3 .703 Admission glycemia (mg/dL) 128.1 ± 38.4 125.4 ± 39.3 135.9 ± 36.3 .465 Systolic blood pressure (mm Hg) 143.5 ± 27.5 146.7 ± 29 134.4 ± 21.2 .205 Diastolic blood pressure (mm Hg) 76.5 ± 15.4 79 ± 15.7 69.4 ± 12.4 .076 Occluded vessel: MCA/terminal ICA 63.3/36.7 62.8/37.2 64.7/35.3 .823 Baseline NIHSS 20 (18–21) 19 (17–21) 21 (18–21) .089 IV-tPA (%) 55 58.1 43.8 .328 Time to IV-tPA (min) 114 ± 47.6 119 ± 52.3 98 ± 20.9 .313 Time to groin 193 ± 77 193 ± 74 192 ± 73 .653 IA-tPA (%) 67.3 55.3 94.1 .005 IA-tPA dose 10.6 (10.6) 16 (9.5) 16.8 (4.7) .254 Merci retriever use 6.6 4.3 11.7 .35 Recanalization 73.2 67.5 87.5 .06 Time from symptom to recanalization 328 (144) 316 (177) 350 (49) .066 Time from groin to recanalization 125 (60) 118 (66) 138 (47) .310 NIHSS at 12 hr 18 (6.5–20) 18 (7–20) 17.5 (6–19.2) .79 NIHSS at 24 hr 16 (3–20) 17 (2.5–20) 13.5 (3–18.5) .544 NIHSS at 48 hr 14.5 (2–20) 14 (2–20) 15 (2–20) .971 NIHSS at 7 days or discharge 13 (2–30) 13.5 (2–30) 10 (1.5–25) .657 24-Hour NIHSS improvement 4 (0–11.5) 3 (0–11) 7 (2–14) .308 Discharge NIHSS improvement 9.5 (−2–16) 7.5 (−9–15) 12 (2.7–16.7) .296 Mortality (%) 26 25.7 26.7 .944 Hemorrhagic transformation (%) 34 27 50 .089 Symptomatic hemorrhagic transformation (%) 5 4.7 5.9 .845 mRS at 3 months 4 (0–6) 3 (1–6) 4 (0–6) .980 mRS 0–2 at 3 months (%) 40.5 40 41.6 .890 a Values are expressed as mean ± SD, median (IR), or percentage.
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