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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointerventionT
Open Access

Neck Injury Is Critical to Elastase-Induced Aneurysm Model

K. Wang, Q. Huang, B. Hong, Y. Xu, W. Zhao, J. Chen, R. Zhao and J. Liu
American Journal of Neuroradiology October 2009, 30 (9) 1685-1687; DOI: https://doi.org/10.3174/ajnr.A1542
K. Wang
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Q. Huang
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B. Hong
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Y. Xu
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W. Zhao
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J. Chen
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R. Zhao
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J. Liu
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    Fig 1.

    Schematic of elastase-induced aneurysms in rabbits in groups 1 and 2. A temporary arcuate aneurysm clip is placed at the origin of the RCCA, indicating the inner edge of clip blade on the juncture of RCCA and right subclavian artery. LCCA indicates left common carotid artery.

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    Fig 2.

    Intravenous digital subtraction angiography in a rabbit from group 1. The aneurysm is stable at 3 weeks, 8 weeks, 4 months, and 6 months after surgery.

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    Fig 3.

    Histopathologic analysis of the right common carotid artery (RCCA) in group 1. A, The RCCA induced by elastase after 3 weeks, stained by ponceau/Victoria blue, becomes an aneurysm with intact elastin in the parent vessel and abrupt termination of the elastic lamina at the margins of aneurysm orifice (original magnification ×40). B, Hematoxylin-eosin staining indicates a thin aneurysm wall, the absence of an inflammatory reaction, and marked loss of cellular elements (original magnification ×200).

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American Journal of Neuroradiology: 30 (9)
American Journal of Neuroradiology
Vol. 30, Issue 9
1 Oct 2009
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Cite this article
K. Wang, Q. Huang, B. Hong, Y. Xu, W. Zhao, J. Chen, R. Zhao, J. Liu
Neck Injury Is Critical to Elastase-Induced Aneurysm Model
American Journal of Neuroradiology Oct 2009, 30 (9) 1685-1687; DOI: 10.3174/ajnr.A1542

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Neck Injury Is Critical to Elastase-Induced Aneurysm Model
K. Wang, Q. Huang, B. Hong, Y. Xu, W. Zhao, J. Chen, R. Zhao, J. Liu
American Journal of Neuroradiology Oct 2009, 30 (9) 1685-1687; DOI: 10.3174/ajnr.A1542
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Cited By...

  • Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization
  • Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model
  • From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment
  • Hemodynamic Changes by Flow Diverters in Rabbit Aneurysm Models: A Computational Fluid Dynamic Study Based on Micro-Computed Tomography Reconstruction
  • Elastase-Induced Rabbit Aneurysms Model Complicated by Thoracic Aortic Aneurysms
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