Research ArticlePEDIATRICS
Open Access
Proton MR Spectroscopy Correlates of Frontal Lobe Function in Healthy Children
A. Ozturk, M. Degaonkar, M.A. Matson, C.T. Wells, E.M. Mahone and A. Horská
American Journal of Neuroradiology August 2009, 30 (7) 1308-1314; DOI: https://doi.org/10.3174/ajnr.A1576
A. Ozturk
M. Degaonkar
M.A. Matson
C.T. Wells
E.M. Mahone

References
- ↵Burruss JW, Hurley RA, Taber KH, et al. Functional neuroanatomy of the frontal lobe circuits. Radiology 2000;214:227–30
- ↵Lichter JB, Cummings JL. Introduction and overview. In: Lichter DG, Cummings JL, eds. Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders. New York: Guilford Press;2001 :1–43
- ↵Castellanos FX, Sonuga-Barke EJ, Milham MP, et al. Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci 2006;10:117–23
- ↵Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev 2000;71:44–56
- ↵Goldberg MC, Mostofsky SH, Cutting LE, et al. Subtle executive impairment in children with autism and children with ADHD. J Autism Dev Disord 2005;35:279–93
- ↵Mahone EM, Pillion JP, Hoffman J, et al. Construct validity of the auditory continuous performance test for preschoolers. Dev Neuropsychol 2005;27:11–33
- ↵D'Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp Brain Res 2000;133:3–11
- ↵Mull BR, Seyal M. Transcranial magnetic stimulation of left prefrontal cortex impairs working memory. Clin Neurophysiol 2001;112:1672–75
- ↵
- ↵Yeo RA, Hill D, Campbell R, et al. Developmental instability and working memory ability in children: a magnetic resonance spectroscopy investigation. Dev Neuropsychol 2000;17:143–59
- Davidson MC, Thomas KM, Casey BJ. Imaging the developing brain with fMRI. Ment Retard Dev Disabil Res Rev 2003;9:161–67
- ↵Paus T, Collins DL, Evans AC, et al. Maturation of white matter in the human brain: a review of magnetic resonance studies. Brain Res Bull 2001;54:255–66
- ↵Barker PB, Lin DDM. In vivo proton MR spectroscopy of the human brain. Prog Nucl Magn Reson Spectrosc 2006;49:99–128
- ↵Barker PB. N-acetyl aspartate: a neuronal marker? Ann Neurol 2001;49:423–24
- ↵Duyn JH, Gillen J, Sobering G, et al. Multisection proton MR spectroscopic imaging of the brain. Radiology 1993;188:277–82
- ↵Dunn LM. Peabody Picture Vocabulary Test. 3rd ed. Bloomington, Minn: Pearson Assessments;1997
- ↵Reich W, Welner Z, Hernajic B. The Diagnostic Interview for Children and Adolescents-IV. North Tonawanda, NY: Multi-Health Systems;1997
- ↵Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association;1994
- ↵Tiffin J. Purdue Pegboard: Examiner's Manual. Chicago, Ill: Science Research Associates;1968
- ↵Thorndike RM, Hagen EP, Sattler JM. Stanford-Binet Intelligence Scales. Itasca, Ill: Riverside Publishing;1986
- ↵Woodcock RW, McGrew KS, Mather N. Woodcock-Johnson III. Itasca, Ill: Riverside Publishing;2001
- ↵Zar J. Biostatistical Analysis. 4th ed. Upper Saddle River, NJ: Prentice Hall;1999 :356
- ↵Ross AJ, Sachdev PS. Magnetic resonance spectroscopy in cognitive research. Brain Res Brain Res Rev 2004;44:83–102
- ↵Yeo RA, Phillips JP, Jung RE, et al. Magnetic resonance spectroscopy detects brain injury and predicts cognitive functioning in children with brain injuries. J Neurotrauma 2006;23:1427–35
- ↵Hunter JV, Thornton RJ, Wang ZJ, et al. Late proton MR spectroscopy in children after traumatic brain injury: correlation with cognitive outcomes. AJNR Am J Neuroradiol 2005;26:482–88
- ↵Trope I, Lopez-Villegas D, Cecil KM, et al. Exposure to lead appears to selectively alter metabolism of cortical gray matter. Pediatrics 2001;107:1437–42
- ↵Simister RJ, McLean MA, Barker GJ, et al. Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy. Neurology 2003;61:897–902
- ↵Filippi CG, Ulug AM, Deck MD, et al. Developmental delay in children: assessment with proton MR spectroscopy. AJNR Am J Neuroradiol 2002;23:882–88
- ↵
- ↵Zabala A, Sanchez-Gonzalez J, Parellada M, et al. Findings of proton magnetic resonance spectrometry in the dorsolateral prefrontal cortex in adolescents with first episodes of psychosis. Psychiatry Res 2007;156:33–42
- ↵
- ↵
- ↵Parry L, Shores A, Rae C, et al. An investigation of neuronal integrity in severe paediatric traumatic brain injury. Child Neuropsychol 2004;10:248–61
- ↵
- ↵Ross AJ, Sachdev PS, Wen W, et al. Cognitive correlates of 1H MRS measures in the healthy elderly brain. Brain Res Bull 2005;66:9–16
- ↵
- ↵Keller MA, Venkatraman TN, Thomas A, et al. Altered neurometabolite development in HIV-infected children: correlation with neuropsychological tests. Neurology 2004;62:1810–17
- ↵
- ↵Chang L, Ernst T, Witt MD, et al. Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naive HIV patients. Neuroimage 2002;17:1638
- ↵Olson BL, Holshouser BA, Britt W 3rd, et al. Longitudinal metabolic and cognitive changes in mild cognitive impairment patients. Alzheimer Dis Assoc Disord 2008;22:269–77
- ↵Babikian T, Freier MC, Ashwal S, et al. MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI. J Magn Reson Imaging 2006;24:801–11
- ↵Jung RE, Brooks WM, Yeo RA, et al. Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain. Proc Biol Sci 1999;266:1375–79
- ↵
- ↵Filley CM. White matter and behavioral neurology. Ann N Y Acad Sci 2005;1064:162–83
- ↵Nagy Z, Westerberg H, Klingberg T. Maturation of white matter is associated with the development of cognitive functions during childhood. J Cogn Neurosci 2004;16:1227–33
- ↵Valenzuela MJ, Sachdev PS, Wen W, et al. Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes. Neuroimage 2000;12:747–56
- ↵Charlton RA, McIntyre DJ, Howe FA, et al. The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Brain Res 2007;1164:108–16. Epub 2007 Jun 21
- ↵Charlton RA, Barrick TR, McIntyre DJ, et al. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology 2006;66:217–22
- ↵Vandermeeren Y, Sebire G, Grandin CB, et al. Functional reorganization of brain in children affected with congenital hemiplegia: fMRI study. Neuroimage 2003;20:289–301
- Kim SG, Ashe J, Hendrich K, et al. Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science 1993;261:615–17
- ↵Chen R, Gerloff C, Hallett M, et al. Involvement of the ipsilateral motor cortex in finger movements of different complexities. Ann Neurol 1997;41:247–54
- ↵Waber DP, De Moor C, Forbes PW, et al. The NIH MRI study of normal brain development: performance of a population-based sample of healthy children aged 6 to 18 years on a neuropsychological battery. J Int Neuropsychol Soc 2007;13:729–46
- ↵
- ↵Ungerleider LG, Courtney SM, Haxby JV. A neural system for human visual working memory. Proc Natl Acad Sci U S A 1998;95:883–90
- ↵Smith EE, Jonides JJ, Koeppe RA, et al. Spatial versus object working memory: PET investigations. J Cognit Neurosci 1995;7:337–56
- ↵Klingberg T. Development of a superior frontal-intraparietal network for visuo-spatial working memory. Neuropsychologia 2006;44:2171–77. Epub 2006 Jan 6
- ↵Baldo JV, Dronkers NF. The role of inferior parietal and inferior frontal cortex in working memory. Neuropsychology 2006;20:529–38.
- ↵Hagino H, Suzuki M, Mori K, et al. Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: a preliminary report. Psychiatry Clin Neurosci 2002;56:499–507
- ↵Mahone EM, Martin R, Kates WR, et al. Neuroimaging correlates of parent ratings of working memory in typically developing children. J Int Neuropsychol Soc 2009;15:31–41
- ↵Moore GJ. Proton magnetic resonance spectroscopy in pediatric neuroradiology. Pediatr Radiol 1998;28:805–14
- ↵Wang Z, Zimmerman RA, Sauter R. Proton MR spectroscopy of the brain: clinically useful information obtained in assessing CNS diseases in children. AJR Am J Roentgenol 1996;167:191–99
- ↵Saykin AJ, Ahles TA, McDonald BC. Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives. Semin Clin Neuropsychiatry 2003;8:201–16
- ↵Castillo M, Kwock L, Courvoisie H, et al. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR Am J Neuroradiol 2000;21:832–38
- ↵Caetano SC, Fonseca M, Olvera RL, et al. Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients. Neurosci Lett 2005;384:321–26
- ↵Friedman SD, Brooks WM, Jung RE, et al. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury. AJNR Am J Neuroradiol 1998;19:1879–85
- ↵Huda A, Guze BH, Thomas A, et al. Clinical correlation of neuropsychological tests with 1H magnetic resonance spectroscopy in hepatic encephalopathy. Psychosom Med 1998;60:550–56
In this issue
Advertisement
A. Ozturk, M. Degaonkar, M.A. Matson, C.T. Wells, E.M. Mahone, A. Horská
Proton MR Spectroscopy Correlates of Frontal Lobe Function in Healthy Children
American Journal of Neuroradiology Aug 2009, 30 (7) 1308-1314; DOI: 10.3174/ajnr.A1576
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
- Exploratory Multisite Magnetic Resonance Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children
- Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy
- Low Cerebellar Vermis Volumes and Impaired Neuropsychologic Performance in Children Treated for Brain Tumors and Leukemia
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement