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Research ArticleHead and Neck Imaging

Response and Progression-Free Survival in Oropharynx Squamous Cell Carcinoma Assessed by Pretreatment Perfusion CT: Comparison with Tumor Volume Measurements

S. Bisdas, Z. Rumboldt, J. Wagenblast, M. Baghi, T.S. Koh, M. Hambek, T.J. Vogl and M.G. Mack
American Journal of Neuroradiology April 2009, 30 (4) 793-799; DOI: https://doi.org/10.3174/ajnr.A1449
S. Bisdas
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Z. Rumboldt
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J. Wagenblast
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M. Baghi
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T.S. Koh
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M. Hambek
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T.J. Vogl
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M.G. Mack
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    Fig 1.

    CECT (A) and PCT parametric maps (B-E) of a male patient with SCCA carcinoma in the oropharynx and oral cavity (arrows) as well as enlarged lymph nodes (arrowheads) in Levels I and II on both sides. B, BF map. C, BV map. D, MTT. E, PS map.

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    Fig 2.

    Kaplan-Meier survival analysis showing the predictive value of tumor volume (A) and BF (B) values for progression-free survival.

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    Fig 3.

    ROC analysis of BF measurements vs recurrence (A) and induction chemotherapy response (B).

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    Table 1:

    Demographic and clinical data

    Pt No.Age (y)/SexTNM StagingTumor ResponsePFS
    140/MT3N2aM0PR6
    234/MT4N2cM0PR14
    357/MT4N1M0SD6
    459/MT4N2cM0SD12
    545/MT4N3M0PR11
    655/FT4N2bM0PR24
    759/MT4N3M0SD4
    862/MT4N2cM0SD24
    961/MT4N3M0SD14
    1047/MT4N2cM0PR15
    1172/MT4N3M0PR6
    1249/MT4N2cM0SD8
    1357/MT4N2cM0PR8
    1464/MT4N1M0PR4
    1553/MT4N2cM0SD11
    1656/MT4N3M0SD5
    1762/FT4N2cM0PR10
    1865/MT4N3M0PR13
    1959/MT4N2cM0PR12
    • Note:—TNM indicates tumors, nodes, and metastasis; PR indicates partial response; SD, stable disease; PFS, progression-free survival (in months).

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    Table 2:

    ROC curve analysis results for the prediction of response to induction chemotherapy based on the pretreatment tumor volume and the perfusion-associated parameters*

    ResponseCutoff ValueSensitivity (%)Specificity (%)AUCP Value
    Pretreatment tumor volume (mL)≤15.3100 (99.1–100)33.3 (26.5–40.7)0.50.84
    Blood flow (mL/100 g/min)≤66.284.2 (79.8–89.7)66.7 (59.3–73.5)0.63.0001
    Blood volume (mL/100 g)>7.4100 (98.9–100)30.6 (23.9–37.8)0.59.0005
    Mean transit time (s)<8.543.7 (38.4–49.1)100 (98–100)0.62.0001
    Permeability (mL/100 g/min)>8.665.4 (60.1–70.4)100 (98–100)0.78.0001
    • Note:—AUC indicates area under the curve.

    • * The values (95% CI) represent thresholds above or below of which the patients will show a response.

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American Journal of Neuroradiology: 30 (4)
American Journal of Neuroradiology
Vol. 30, Issue 4
April 2009
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Cite this article
S. Bisdas, Z. Rumboldt, J. Wagenblast, M. Baghi, T.S. Koh, M. Hambek, T.J. Vogl, M.G. Mack
Response and Progression-Free Survival in Oropharynx Squamous Cell Carcinoma Assessed by Pretreatment Perfusion CT: Comparison with Tumor Volume Measurements
American Journal of Neuroradiology Apr 2009, 30 (4) 793-799; DOI: 10.3174/ajnr.A1449

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Response and Progression-Free Survival in Oropharynx Squamous Cell Carcinoma Assessed by Pretreatment Perfusion CT: Comparison with Tumor Volume Measurements
S. Bisdas, Z. Rumboldt, J. Wagenblast, M. Baghi, T.S. Koh, M. Hambek, T.J. Vogl, M.G. Mack
American Journal of Neuroradiology Apr 2009, 30 (4) 793-799; DOI: 10.3174/ajnr.A1449
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