Article Figures & Data
Figures
- Fig 1.
Patient 1 with a grade I meningioma. Images show the effect of resting state versus motor activity on the BOLD signal intensity. B−E, Seed points in the tumor (B and C) or motor area (D and E) are analyzed during resting or motor activity. There is no difference in the highlighted areas and their signals, whether the VOIs are selected while the patient is at rest or finger tapping. A, Anatomic map. B and C, Correlation map and time series for a tumor seed (arrow) in the resting paradigm (B, B’) and in the bilateral tapping paradigm (C, C’). D and E, Correlation map and time series for a normal VOI (arrow) in the resting paradigm (D, D’), and the bilateral tapping paradigm (E, E’). Arrows indicate VOI seed points.
- Fig 2.
Patient 7 with an oligodendroglioma. Images show identification of the tumor or normal area based on voxel seed points. Selection of a VOI in the tumor does not highlight voxels in the surrounding brain; VOIs in the brain do not highlight voxel tumors. A, Anatomic image. B, Tumor (arrow at VOI: x = 27, y = 26, z = 25) and (B’) BOLD signal intensity at R = 0.9917. C, Normal brain tissue (arrow) and BOLD signal intensity (C’) at VOI: x = 18, y = 16, z = 22) at R = 0.9301.
- Fig 3.
Patient 12 with a metastatic tumor. Images show identification of the motor cortex (heavy solid arrow) during bilateral finger tapping. The motor area is identified from the characteristic signal peaks. Selection of a voxel in the motor area (solid arrow) highlights both motor areas and the supplementary motor area but does not highlight voxels in the tumor mass.
Tables
Patient Age (yr) Tumor/Grade* Tumor Volume (cm3) Tumor R Value† Normal R Value† Tumor Correlation‡ Normal-to-Tumor Correlation§ 1 46 Men/I 100.46 0.99 0.98 0.78 0.1 to −0.15 2 41 HMen/II 9.2 0.99 0.96 0.77 0.44–0.32 3 61 AMen/II Nt 0.99 0.93 0.77 0.31–0.05 4 57 Men/I 29.5 0.99 0.98 0.83 −0.44–0.05 5 56 AMen/II 61.5 0.99 0.96 0.92 0.49–0.45 6 54 Oligogl/II 26.03 0.99 0.98 0.79 0.32 to −0.02 7‖ 28 Oligogl/II 99.07 0.99 0.93 0.86 0.22–0.03 8 58 Glioblast/IV 7.87 0.99 0.95 0.73 0.48–0.29 9 37 Oligogl/II 67.3 0.99 0.99 0.53 0.15–0.05 10‖ 30 Oligogl/III 39.5 0.99 0.93 0.86 0.36–0.01 11 26 Oligogl/II 30.9 0.99 0.95 0.46 0.28–0.05 12 28 Met/NG Nt 0.91 0.84 0.83 0.45–0.35 13 58 Met/NG Nt 0.94 0.82 0.97 0.12 to −0.02 14 63 Met/NG¶ Nt 0.96 0.91 – – Note:—Men indicates meningioma; HMen, hemangiopericytoma; Amen, atypical meningioma; Oligogl, oligodendroglioma; Glioblast, glioblastoma; Met, metastatic; Nt, not taken; NG, not graded; –, only 1 seed point in this tumor.
* Tumor Grade means WHO classification grades I–IV or NG.
† The correlation coefficient where maximum tumor area is highlighted (tumor R value) or maximum normal area is highlighted and the tumor is excluded (normal R value).
‡ The mean Pearson correlation coefficients comparing the BOLD signals from several voxels or seed points of interest (VOIs) within the same tumor.
§ Normal Correlation indicates the mean Pearson correlation coefficient comparing the BOLD signals in the tumor with normal tissue. Normal/Tumor Correlation indicates the range of Pearson correlation coefficients comparing a tumor VOI to 3 VOIs outside the tumor.
‖ Patients 7 and 10 are the same person diagnosed and treated 1 year apart.
¶ Only 1 seed could be taken from this tumor.
Patient Tumor Normal Resting† Motor‡ Resting† Motor‡ 1 0.9917 0.9947 0.9709 0.9795 6 0.9961 0.9961 0.9600 0.9870 Note:—BOLD indicates blood oxygen level–dependent.
* Tumor resting-versus-motor P value is .3089. Normal resting-versus-motor P value is .0651.
† Tumor seed: x = 20, y = 24, z = 16.
‡ Normal seed: x = 31, y = 24, z = 16.
