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Research ArticleNeurointervention

The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism

A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca and S. Po Sit for the Penumbra Phase 1 Stroke Trial Investigators
American Journal of Neuroradiology August 2008, 29 (7) 1409-1413; DOI: https://doi.org/10.3174/ajnr.A1110
A. Bose
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H. Henkes
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K. Alfke
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W. Reith
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T.E. Mayer
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A. Berlis
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V. Branca
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S. Po Sit
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    Fig 1.

    Schematic diagram of the Penumbra device.

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    Fig 2.

    Angiographic illustration of a target vessel before (A) and after (B) treatment by the PS. This patient was a 66-year-old man who presented 3 hours from symptom onset with an NIHSS score of 24, which improved to 8 at 24 hours after revascularization by the PS. He continued to recover with a 30-day NIHSS score of 2 and an mRS of 1.

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    Fig 3.

    Subjects outcome based on baseline NIHSS scores.

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    Fig 4.

    A comparison of the observed and expected mortality rates for the entire study cohort and after stratification by location of the target vessel. The expected rates were derived from historical rates from the natural history of the disease reported in the literature, prorated to the proportion of target vessel locations treated in this study (see References 1–3).

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  • TIMI scores (core laboratory adjudicated)

    VariableBaseline (N = 21), % (n/N)Posttreatment (N = 21), % (n/N)
    TIMI 090 (19/21)0 (0/21)
    TIMI 110 (2/21)0 (0/21)
    TIMI 20 (0/21)48 (10/21)
    TIMI 30 (0/21)52 (11/21)
    • Note:—Twenty-one target vessels were treated in 20 subjects. TIMI indicates Thrombolysis in Myocardial Infarction.

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American Journal of Neuroradiology: 29 (7)
American Journal of Neuroradiology
Vol. 29, Issue 7
August 2008
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A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca, S. Po Sit
The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism
American Journal of Neuroradiology Aug 2008, 29 (7) 1409-1413; DOI: 10.3174/ajnr.A1110

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The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism
A. Bose, H. Henkes, K. Alfke, W. Reith, T.E. Mayer, A. Berlis, V. Branca, S. Po Sit
American Journal of Neuroradiology Aug 2008, 29 (7) 1409-1413; DOI: 10.3174/ajnr.A1110
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