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Research ArticleNeurointervention

Detection of Aneurysms by 64-Section Multidetector CT Angiography in Patients Acutely Suspected of Having an Intracranial Aneurysm and Comparison with Digital Subtraction and 3D Rotational Angiography

A.M. McKinney, C.S. Palmer, C.L. Truwit, A. Karagulle and M. Teksam
American Journal of Neuroradiology March 2008, 29 (3) 594-602; DOI: https://doi.org/10.3174/ajnr.A0848
A.M. McKinney
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C.S. Palmer
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C.L. Truwit
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A. Karagulle
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M. Teksam
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    Fig 1.

    An 83-year-old woman with SAH and an aneurysm less than 4 mm. Emergent CTA showed a 2-mm MCA bifurcation aneurysm. This was difficult to visualize on conventional DSA (not shown) but was confirmed on 3DRA (B) and surgically.

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    Fig 2.

    A 47-year-old woman with SAH and multiple 4- to 10-mm aneurysms; aneurysm measurement technique is demonstrated. MSCTA showed 3 aneurysms: a 7 mm basilar tip aneurysm (arrowhead, A), a right posterior communicating artery (PcomA) segment aneurysm (solid arrow, A), and a fenestrated, fusiform anterior communicating artery (AcomA, dashed arrow, A). Sectioned 3D (B, top) and MPR (B, bottom) images were used to measure the PcomA aneurysm. 3DRA demonstrated the PcomA (gold arrow denotes the site of hemorrhage, C) and the double-fenestration AcomA (dashed red arrows, C).

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    Fig 3.

    A 78-year-old woman with SAH from an aneurysm more than 10 mm in size. MSCTA showed a 12-mm aneurysm in the periophthalmic ICA segment on 3D-VR images (data not shown), with peripheral calcifications, best seen on MPR (short white arrows, A). The aneurysm was noted to be separate from the ophthalmic artery origin on 3DRA (black arrow, B).

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    Fig 4.

    The only false-negative CTA, in a 72-year-old man with severe headache, lacking hemorrhage on CT. However, the symptoms prompted an MR imaging/MR angiography (data not shown), with tiny infarcts and a questionable left supraclinoid ICA outpouching. Thereafter, the patient underwent catheter DSA to exclude vasculitis (which was negative), which showed a 2-mm periophthalmic aneurysm on 3DRA (dashed arrow, A). Closer, repeat review of the CTA showed the lesion projecting medially over the bony sella (arrow, B).

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    Fig 5.

    The only false-positive CTA. A 38-year-old woman with confusion had a head CT negative for hemorrhage but with an isoattenuated structure in the region of the left MCA (data not shown) and corresponding flow void on T2-weighted MR imaging (data not shown), suspicious for aneurysm. Both 16-section (data not shown) and repeat 64-section CTA were performed, which showed a bizarre 6- to 7-mm outpouching (question marks, A and B) overlying the left MCA bifurcation on MPR axial (A, top) and coronal (A, bottom) and 3D MIP/VR posterior (B, top) and superior (B, bottom) views. This was considered a prominent middle cerebral venous plexus, because the catheter DSA and 3DRA (data not shown) were completely negative.

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    Fig 6.

    Blisterlike lesion in a 46-year-old man with SAH from a 3.5-mm MCA aneurysm, noted on CTA and 3DRA (asterisk, A). The sessile lesion was noted on the undersurface of the ICA and not noted on CTA 3D-VR (data not shown) or MPR (B) views. This was not changed on 2-week repeat catheter 3DRA.

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    Fig 7.

    Atherosclerosis simulating a blister-like lesion. A 52-year-old woman with SAH and focal parenchymal hematoma on CT. CTA showed a 2.9-mm M3 mycotic aneurysm adjacent to the hematoma, also present on 3DRA (dashed arrows, A and B). However, a sessile outpouching was noted on the cavernous ICA undersurface (solid arrows, A and B). Further review of the CTA MPR images revealed this to be an atherosclerotic calcification (pink arrow, C).

Tables

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    Table 1:

    Aneurysm detection by MSCTA, confirmation by DSA/3DRA, and locations

    Aneurysm Size, mmCTA: No. of Aneurysms*DSA: No. of CTA True-PositivesDSA: No. of CTA False-NegativesDSA: No. of CTA False-PositivesAneurysm Locations (No.) of Each Size Range as on DSA
    <4151310AcomA (1)
    ACA: A1/A2 Bif (2)
    ICA: cavernous (1)
    ICA: periophthalmic (2)
    ICA: PcomA segment/origin (3)
    MCA: Bif/Trif (2)
    MCA: M2 segment (2)
    4–10201801AcomA (4)
    ICA: PcomA segment/origin (7)
    ICA: terminus (1)
    MCA: Bif/Trif (4)
    Basilar: tip (1)
    Basilar: midportion (1)
    >106600AcomA (2)
    ICA: periophthalmic (1)
    ICA: PcomA segment/origin (1)
    ICA: terminus (1)
    MCA: Bif/Trif (1)
    Total413711AcomA (7)
    ACA: A1/A2 Bif (2)
    ICA: cavernous (1)
    ICA: periophthalmic (3)
    ICA: PcomA segment/origin (11)
    ICA: terminus (2)
    MCA: Bif/Trif (7)
    MCA: M2 segment (2)
    Basilar: (2)
    • Note:—PcomA indicates posterior communicating artery; AcomA, anterior communicating artery; Bif/Trif, bifurcation/trifurcation; ICA, internal carotid artery; MSCTA, multisection CT angiography; DSA, digital subtraction angiography; 3DRA, 3D rotational angiography; CTA, CT angiography; ACA, anterior cerebral artery.

    • * Note: Number of aneurysms on CTA includes 2 patients with aneurysms who did not undergo DSA/3DRA.

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    Table 2:

    Accuracy of 64MSCTA on a per-aneurysm/per-patient basis, with κ and ρ per size

    Size on DSA/RASensitivity of MSCTA, %Specificity of MSCTA, %PPV of MSCTA, %NPV of MSCTA, %Accuracy of MSCTA, %κ/ρ (CTA versus DSA) Aneurysm Size
    Overall97.4/96.090.0/90.097.4/96.090.0/90.095.8/94.30.965/0.967
    <4 mm92.3/90.9100.0/100.0100.0/100.090.9/90.995.2/95.60.711/0.753
    4–10 mm100.0/100.090.0/90.994.7/92.3100.0/100.095.8/96.40.841/0.861
    >10 mm100.0/100.0100.0/100.0100.0/100.0100.0/100.0100.0/100.00.476/0.888
    • Note:—MSCTA indicates multisection CT angiography; DSA, digital subtraction angiography; RA, rotational angiography; κ = κ reliability coefficient, ρ = ρ correlation coefficient; CTA, CT angiography. Data show a per-aneurysm/per-patient percentages.

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American Journal of Neuroradiology: 29 (3)
American Journal of Neuroradiology
Vol. 29, Issue 3
March 2008
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A.M. McKinney, C.S. Palmer, C.L. Truwit, A. Karagulle, M. Teksam
Detection of Aneurysms by 64-Section Multidetector CT Angiography in Patients Acutely Suspected of Having an Intracranial Aneurysm and Comparison with Digital Subtraction and 3D Rotational Angiography
American Journal of Neuroradiology Mar 2008, 29 (3) 594-602; DOI: 10.3174/ajnr.A0848

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Detection of Aneurysms by 64-Section Multidetector CT Angiography in Patients Acutely Suspected of Having an Intracranial Aneurysm and Comparison with Digital Subtraction and 3D Rotational Angiography
A.M. McKinney, C.S. Palmer, C.L. Truwit, A. Karagulle, M. Teksam
American Journal of Neuroradiology Mar 2008, 29 (3) 594-602; DOI: 10.3174/ajnr.A0848
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