Article Figures & Data
Figures
- Fig 1.
ADC and FA measurements in a 22-year-old man with pathologically confirmed lymphoma in the right temporo-occipital region. A, Axial contrast-enhanced T1-weighted MR image (781/8.1) shows an enhancing mass in the right temporo-occipital region. There are enhancing nodules along the right frontal ependymal surface. There is a rim-enhancing nodule posteromedial to the main mass; cystic change or necrosis of the tumor is considered. One ROI is in the enhancing tumor area for measurement of ADC and FA values, and another ROI is at a corresponding site in the contralateral NAWM. On FA (B) and ADC (C) maps, the ROIs in A are superimposed.
- Fig 2.
ADC and FA measurements in a 45-year-old woman with pathologically confirmed GBM in the left frontal region. A, Axial contrast-enhanced T1-weighted MR image (350/2.5) shows an enhancing mass in the left frontal region. One ROI is in the enhancing tumor area for measurement of ADC and FA values, and another ROI is at a corresponding site in the contralateral NAWM. On FA (B) and ADC (C) maps, the ROIs in A are superimposed.
- Fig 3.
Scatterplot of FA versus ADC measured in solid enhancing tumors and contralateral NAWM. Measurements from lymphomas tend to cluster in the area corresponding with FA and ADC decreases, whereas measurements from GBMs tend to cluster in area corresponding with FA decreases and ADC increases.
Tables
Variable Lymphoma GBM P 95% CI FA 0.140 ± 0.024 0.229 ± 0.069 .001 −0.137 to −0.040 FA ratios 0.25 ± 0.04 0.40 ± 0.12 .002 −0.234 to −0.064 ADC (×10−3 mm2/s) 0.630 ± 0.155 0.963 ± 0.119 <.001 −0.463 to −0.203 ADC ratios 0.83 ± 0.14 1.26 ± 0.13 <.001 −0.558 to −0.304 Note:—Data are the mean ± SD. FA indicates fractional anisotropy; ADC, apparent diffusion coefficient; GBM, glioblastoma multiforme; CI, confidence interval. ADC and FA ratios were calculated by dividing the mean ADC or FA values of the affected hemisphere by those of the normal-appearing white matter of the contralateral hemisphere.
- Table 2:
Measures of sensitivity, specificity, and accuracy in discrimination of lymphomas from GBMs with receiver operating characteristic curve analysis
Variable CV Sensitivity, % Specificity, % Accuracy, % AUC, % P FA 0.192 100 80 90 0.87 .005 FA ratios 0.330 100 80 90 0.84 .010 ADC 0.818 100 90 95 0.97 <.001 ADC ratios 1.060 100 100 100 1.00 <.001 Note:—FA indicates fractional anisotropy; ADC, apparent diffusion coefficient; GBM, glioblastoma multiforme; CV, cutoff value; AUC, area under the curve.
In this issue
Jump to section
Related Articles
Cited By...
- CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma
- Differentiation of Enhancing Glioma and Primary Central Nervous System Lymphoma by Texture-Based Machine Learning
- Combining Diffusion Tensor Metrics and DSC Perfusion Imaging: Can It Improve the Diagnostic Accuracy in Differentiating Tumefactive Demyelination from High-Grade Glioma?
- Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI
- Role of MRI in Primary Brain Tumor Evaluation
- Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging
- Atypical Imaging Features of Epstein-Barr Virus-Positive Primary Central Nervous System Lymphomas in Patients without AIDS
- Differentiation of Primary Central Nervous System Lymphomas and Glioblastomas: Comparisons of Diagnostic Performance of Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging without and with Contrast-Leakage Correction
- Differentiation of Tumefactive Demyelinating Lesions from High-Grade Gliomas with the Use of Diffusion Tensor Imaging
- Differentiation of Brain Abscesses from Necrotic Glioblastomas and Cystic Metastatic Brain Tumors with Diffusion Tensor Imaging
- Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging
- Differentiation between Glioblastomas, Solitary Brain Metastases, and Primary Cerebral Lymphomas Using Diffusion Tensor and Dynamic Susceptibility Contrast-Enhanced MR Imaging
- Leukemic Infiltrative Plexopathy: Diagnosis and Follow-Up with Diffusion Tensor Imaging
- Diffusion-Weighted MR Imaging Derived Apparent Diffusion Coefficient Is Predictive of Clinical Outcome in Primary Central Nervous System Lymphoma