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Research ArticleNeurointervention

The Impact of Cavernous Sinus Drainage Pattern on the Results of Venous Sampling in Patients With Suspected Cushing Syndrome

N. Hayashi, M. Kurimoto, M. Kubo, N. Kuwayama, K. Kurosaki, S. Nagai and S. Endo
American Journal of Neuroradiology January 2008, 29 (1) 69-72; DOI: https://doi.org/10.3174/ajnr.A0745
N. Hayashi
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M. Kurimoto
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M. Kubo
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N. Kuwayama
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K. Kurosaki
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S. Nagai
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S. Endo
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    Fig 1.

    Anteroposterior view of cavernous sinography in case 5, demonstrating that the main drainage route was the IPS bilaterally.

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    Fig 2.

    Lateral view of right cavernous sinography in case 1, showing that the pterygoid plexus was developed to the same extent as the IPS. Note that the opacification of the pterygoid plexus is more than the one of the IPS, but this may be due to the rate and the force of injection of contrast material.

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    Fig 3.

    Anteroposterior view of right cavernous sinography in case 4, showing the tip of the microcatheter (arrow) in the CS (right) and that the main drainage route is via the pterygoid plexus (left). Note that the microcatheter is introduced through the IPS into the CS and that contrast material moves from the CS into the pterygoid plexus.

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    Table 1:

    Intracavernous and petrosal sinus gradient of ACTH levels

    Case No.Age, y, SexSideDrainage RouteCentral/Peripheral Ratio of ACTH Level
    Ant.Mid.Post.IPS
    158, FrtPP, IPS1.01.41.31.0
    ltIPS4.91.512.67.0
    263, FrtIPS1.01.01.01.0
    ltIPS1.01.01.00.9
    345, FrtPP, IPS8.48.411.80.8
    ltPP, IPS4.924.367.82.3
    441, FrtPP34.85.30.90.8
    ltIPS0.90.80.80.8
    566, FrtIPS––2.14.6
    ltIPS1.31.31.62.5
    • Note:— IPS indicates inferior petrosal sinus; PP, pterygoid plexus; Ant., anterior; Mid., middle; Post, posterior; rt, right; lt, left; F, female; ACTH, adrenocorticotropic hormone.

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    Table 2:

    Intercavernous and interpetrosal gradients of ACTH levels in 4 patients with pituitary adenoma

    Case No.Location of AdenomaHighest ACTH Level in Each CS, pg/mLIntercavernous GradientsACTH Level in IPS, pg/mLInterpetrosal Gradients
    RtLtRtLt
    1lt201768.8 (lt)15986.5 (lt)
    3lt6960561008.1 (lt)62318803,0 (lt)
    4rt25406837.4 (rt)61551.1 (rt)
    5rt2702091.3 (rt)5933201.9 (rt)
    • Note:—ACTH, adrenocorticotropic hormone; lt, left; rt, right; IPS, inferior petrosal sinus; CS, cavernous sinus.

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American Journal of Neuroradiology: 29 (1)
American Journal of Neuroradiology
Vol. 29, Issue 1
January 2008
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N. Hayashi, M. Kurimoto, M. Kubo, N. Kuwayama, K. Kurosaki, S. Nagai, S. Endo
The Impact of Cavernous Sinus Drainage Pattern on the Results of Venous Sampling in Patients With Suspected Cushing Syndrome
American Journal of Neuroradiology Jan 2008, 29 (1) 69-72; DOI: 10.3174/ajnr.A0745

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The Impact of Cavernous Sinus Drainage Pattern on the Results of Venous Sampling in Patients With Suspected Cushing Syndrome
N. Hayashi, M. Kurimoto, M. Kubo, N. Kuwayama, K. Kurosaki, S. Nagai, S. Endo
American Journal of Neuroradiology Jan 2008, 29 (1) 69-72; DOI: 10.3174/ajnr.A0745
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