Hypoxic-Ischemic Brain Injury in the Neonatal Rat Model: Relationship between Lesion Size at Early MR Imaging and Irreversible Infarction

References

1. ↵
   Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev 2001;7:56–64

   CrossRefPubMedWeb of Science
2. ↵
   Adcock KH, Nedelcu J, Loenneker T, et al. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. Dev Neurosci 2002;24:382–88

   CrossRefPubMedWeb of Science
3. Lee JH, Lee YK, Ishikawa M, et al. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats–an MRI study. Brain Res 2003;994:91–98

   CrossRefPubMedWeb of Science
4. Petty MA, Neumann-Haefelin C, Kalisch J, et al. In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic stroke. Eur J Pharmacol 2003;474:53–62

   PubMed
5. ↵
   Johnston MV, Trescher WH, Ishida A, et al. Novel treatments after experimental brain injury. Semin Neonatol 2000;5:75–86

   CrossRefPubMed
6. ↵
   Nedelcu J, Klein MA, Aguzzi A, et al. Resuscitative hypothermia protects the neonatal rat brain from hypoxic-ischemic injury. Brain Pathol 2000;10:61–71

   PubMedWeb of Science
7. Wagner BP, Nedelcu J, Martin E. Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. Pediatr Res 2002;51:354–60

   PubMedWeb of Science
8. Williams GD, Dardzinski BJ, Buckalew AR, et al. Modest hypothermia preserves cerebral energy metabolism during hypoxia-ischemia and correlates with brain damage: a 31P nuclear magnetic resonance study in unanesthetized neonatal rats. Pediatr Res 1997;42:700–708

   PubMedWeb of Science
9. ↵
   Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;19:365:663–70
10. ↵
    Hagberg H, Bona E, Gilland E, et al. Hypoxia-ischaemia model in the 7-day-old rat: possibilities and shortcomings. Acta Paediatr Suppl 1997;422:85–88

    PubMed
11. ↵
    Hagberg H, Ichord R, Palmer C, et al. Animal models of developmental brain injury: relevance to human disease: a summary of the panel discussion from the Third Hershey Conference on Developmental Cerebral Blood Flow and Metabolism. Dev Neurosci 2002;24:364–66

    CrossRefPubMedWeb of Science
12. ↵
    Vannucci RC, Connor JR, Mauger DT, et al. Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res 1999;55:158–63

    CrossRefPubMedWeb of Science
13. ↵
    Roohey T, Raju TN, Moustogiannis AN. Animal models for the study of perinatal hypoxic-ischemic encephalopathy: a critical analysis. Early Hum Dev 1997;47:115–46

    CrossRefPubMedWeb of Science
14. ↵
    Qiao M, Malisza KL, Del Bigio MR, et al. Transient hypoxia-ischemia in rats: changes in diffusion-sensitive MR imaging findings, extracellular space, and Na+-K+ -adenosine triphosphatase and cytochrome oxidase activity. Radiology 2002;223:65–75

    CrossRefPubMedWeb of Science
15. ↵
    Ringer TM, Neumann-Haefelin T, Sobel RA, et al. Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia. Stroke 2001;32:2362–69

    Abstract/FREE Full Text
16. ↵
    Lythgoe MF, Thomas DL, Calamante F, et al. Acute changes in MRI diffusion, perfusion, T(1), and T(2) in a rat model of oligemia produced by partial occlusion of the middle cerebral artery. Magn Reson Med 2000;44:706–12

    CrossRefPubMedWeb of Science
17. ↵
    Ordidge R, Thornton J, Clemence M, et al. NMR studies of hypoxic-ischaemic injury in neonatal brain using imaging and spectroscopy. Adv Exp Med Biol 1997;428:539–44

    PubMed
18. ↵
    Tuor UI, Kozlowski P, Del Bigio MR, et al. Diffusion- and T2-weighted increases in magnetic resonance images of immature brain during hypoxia-ischemia: transient reversal posthypoxia. Exp Neurol 1998;150:321–28

    CrossRefPubMedWeb of Science
19. ↵
    Nedelcu J, Klein MA, Aguzzi A, et al. Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damage. Pediatr Res 1999;46:297–304

    PubMedWeb of Science
20. ↵
    Miyasaka N, Nagaoka T, Kuroiwa T, et al. Histopathologic correlates of temporal diffusion changes in a rat model of cerebral hypoxia/ischemia. AJNR Am J Neuroradiol 2000;21:60–66

    Abstract/FREE Full Text
21. ↵
    Rumpel H, Nedelcu J, Aguzzi A, et al. Late glial swelling after acute cerebral hypoxia-ischemia in the neonatal rat: a combined magnetic resonance and histochemical study. Pediatr Res 1997;42:54–59

    PubMedWeb of Science
22. Miyasaka N, Kuroiwa T, Zhao FY, et al. Cerebral ischemic hypoxia: discrepancy between apparent diffusion coefficients and histologic changes in rats. Radiology 2000;215:199–204

    PubMed
23. ↵
    Ning G, Malisza KL, Del Bigio MR, et al. Magnetic resonance imaging during cerebral hypoxia-ischemia: T2 increases in 2-week-old but not 4-week-old rats. Pediatr Res 1999;45:173–79

    PubMedWeb of Science
24. ↵
    Olah L, Wecker S, Hoehn M. Secondary deterioration of apparent diffusion coefficient after 1-hour transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000;20:1474–82

    CrossRefPubMed
25. ↵
    Iadecola C, Zhang F, Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 1995;268:R286–92
26. ↵
    McRae A, Gilland E, Bona E, et al. Microglia activation after neonatal hypoxic-ischemia. Brain Res Dev Brain Res 1995;84:245–52

    CrossRefPubMed
27. ↵
    Olah L, Wecker S, Hoehn M. Relation of apparent diffusion coefficient changes and metabolic disturbances after 1 hour of focal cerebral ischemia and at different reperfusion phases in rats. J Cereb Blood Flow Metab 2001;21:430–39

    CrossRefPubMedWeb of Science
28. ↵
    Hoehn-Berlage M, Norris DG, Kohno K, et al. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 1995;15:1002–11

    CrossRefPubMedWeb of Science