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Research ArticleBrain

Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results

J. Claude Hemphill, Wade S. Smith, D. Christian Sonne, Diane Morabito and Geoffrey T. Manley
American Journal of Neuroradiology May 2005, 26 (5) 1095-1100;
J. Claude Hemphill III
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Wade S. Smith
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D. Christian Sonne
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Diane Morabito
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Geoffrey T. Manley
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    Fig 1.

    Patient who underwent hemicraniectomy after head trauma.

    A, Nonenhanced CT scan shows the tip of the brain-tissue oxygen probe as a white linear attenuation in the right hemispheric white matter. Midline white attenuation is a ventriculostomy catheter. Yellow circle indicates the ROI for CTP analysis.

    B, CTP color map of MTT. On the reference bar, blue indicates the slowest MTT. Arrow points to the tip of the oxygen probe. Overall, MTT is decreased on the side of hemicraniectomy, indicating more rapid transit. Surrounding blue rim represents scalp perfusion.

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    Fig 2.

    Plots of PbrO2.

    A, PbrO2 is inversely and significantly correlated with MTT (P = .017).

    B and C, PbrO2 is not significantly related to CBV or CBF.

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    TABLE 1:

    Physiologic variables in 22 subjects during CTP and CTP findings

    VariableValue
    Mean arterial pressure (mm Hg)98 ± 12
    Intracranial pressure (mm Hg)15 ± 6
    Cerebral perfusion pressure (mm Hg)83 ± 11
    FiO20.41 ± 0.12
    PbrO2 (mm Hg)27.6 ± 13.3
    Mean Transit Time (second)3.83 ± 1.09
    CBV (mL/100 g)3.94 ± 1.95
    CBF (mL/100 g/min)59.7 ± 38.1
    • Note.—Data are the mean ± standard deviation.

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    TABLE 2:

    Multivariable model of the relationship between physiologic parameters and MTT

    ParameterCoefficient*95% Confidence IntervalP Value
    PbrO2 (mm Hg)−0.42−0.72, −0.12.006
    FiO20.42−4.18, 42.6.98
    Cerebral perfusion pressure (mm Hg)0.04−0.38, 0.46.85
    • * Expressed per 10-mm Hg change in PbrO2 and cerebral perfusion pressure and per 0.10 change in FiO2.

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American Journal of Neuroradiology: 26 (5)
American Journal of Neuroradiology
Vol. 26, Issue 5
1 May 2005
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Cite this article
J. Claude Hemphill, Wade S. Smith, D. Christian Sonne, Diane Morabito, Geoffrey T. Manley
Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results
American Journal of Neuroradiology May 2005, 26 (5) 1095-1100;

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Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results
J. Claude Hemphill, Wade S. Smith, D. Christian Sonne, Diane Morabito, Geoffrey T. Manley
American Journal of Neuroradiology May 2005, 26 (5) 1095-1100;
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