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Research ArticleBrain

Carotid Plaque Composition and Cerebral Infarction: MR Imaging Study

Mohamed Ouhlous, H. Zwenneke Flach, Thomas T. de Weert, Johanna M. Hendriks, Marc R. H. M. van Sambeek, Diederik W. J. Dippel, Peter M. T. Pattynama and Aad van der Lugt
American Journal of Neuroradiology May 2005, 26 (5) 1044-1049;
Mohamed Ouhlous
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H. Zwenneke Flach
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Thomas T. de Weert
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Johanna M. Hendriks
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Marc R. H. M. van Sambeek
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Diederik W. J. Dippel
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Peter M. T. Pattynama
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Aad van der Lugt
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    Fig 1.

    Axial lack-blood fast spin-echo images of the internal carotid artery (ICA) and external carotid artery (ECA). Comparison of images reveals no changes in relative signal intensity of the plaque. Hyperintense region is fibrous tissue, and hypointense spots are calcifications.

    A, Proton density-weighted image. L = lumen.

    B, Corresponding T2-weighted image. Plaque in the ICA is mainly hyperintense, with hypointense spots.

  • Fig 2.
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    Fig 2.

    Axial lack-blood fast spin-echo images of the ICA (arrow). Plaque in the ICA is hyperintense. L = lumen.

    A and B, Proton density-weighted (A) and corresponding T2-weighted (B) images. Large region of the plaque has intermediate signal intensity, with hyperintense edges.

    C and D, Another patient. Proton density-weighted (C) and corresponding T2-weighted (D) images. Plaque in the ICA has a large region of intermediate signal intensity, which is relatively decreased in D, while the rest of the plaque remains hyperintense.

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    Fig 3.

    t-FLAIR images of the brain.

    A, Cortical infarct in the territory of the left middle cerebral artery.

    B, Centrum semiovale infarct (arrow) in the left hemisphere.

    C, White matter lesion (arrow) in the right hemisphere.

Tables

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    TABLE 1:

    Imaging protocol

    ParametersBlack-Blood Fast Spin-Echo
    Proton Density WeightedT2 Weightedt-FLAIR*
    TR (msec)2 heartbeats2 heartbeats8000
    TE (msec)1450100
    Band width (kHz)2020
    Field of view (mm)6060240
    Section thickness (mm)335
    MATRIX256 × 256256 × 256256 × 192
    NEX221
    Echo train length1212
    TI (msec)NANA2000
    GatingCardiacCardiacNA
    Sections8824
    Resolution (μm)234 × 234234 × 234937 × 1250
    Imaging time (min)882.5
    • Note.—NA = not applicable.

    • * Turbo fluid-attenuated inversion recovery.

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    TABLE 2:

    Relationship between plaque composition and cerebral lesions

    LesionLipid Core (n = 25)No Lipid Core (n = 16)P Value*
    Basal ganglia infarct
        No. of patients2 (8)0 (0).51
        Median no. of lesions1.5 (1–2)NA
    Centrum semiovale infarct
        No. of patients14 (56)4 (25).06
        Median no. of lesions1 (0–6)0 (0–4).04
    Cortical infarct
        No. of patients6 (24)3 (19).99
    Any infarct
        No. of patients17 (68)5 (31).03
    White matter lesions
        No. of patients21 (84)13 (81).99
        Median no. of lesions3 (0–9)2 (0–12).16
    • Note.—Data in parentheses are the percentage or the range. NA = not applicable.

    • * Group with a lipid core versus and group without a lipid core.

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American Journal of Neuroradiology: 26 (5)
American Journal of Neuroradiology
Vol. 26, Issue 5
1 May 2005
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Cite this article
Mohamed Ouhlous, H. Zwenneke Flach, Thomas T. de Weert, Johanna M. Hendriks, Marc R. H. M. van Sambeek, Diederik W. J. Dippel, Peter M. T. Pattynama, Aad van der Lugt
Carotid Plaque Composition and Cerebral Infarction: MR Imaging Study
American Journal of Neuroradiology May 2005, 26 (5) 1044-1049;

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Carotid Plaque Composition and Cerebral Infarction: MR Imaging Study
Mohamed Ouhlous, H. Zwenneke Flach, Thomas T. de Weert, Johanna M. Hendriks, Marc R. H. M. van Sambeek, Diederik W. J. Dippel, Peter M. T. Pattynama, Aad van der Lugt
American Journal of Neuroradiology May 2005, 26 (5) 1044-1049;
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  • 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance
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