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Research ArticleBrain

Differentiation of Low-Grade Oligodendrogliomas from Low-Grade Astrocytomas by Using Quantitative Blood-Volume Measurements Derived from Dynamic Susceptibility Contrast-Enhanced MR Imaging

Soonmee Cha, Tarik Tihan, Forrest Crawford, Nancy J. Fischbein, Susan Chang, Andrew Bollen, Sarah J. Nelson, Michael Prados, Mitchel S. Berger and William P. Dillon
American Journal of Neuroradiology February 2005, 26 (2) 266-273;
Soonmee Cha
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Tarik Tihan
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Forrest Crawford
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Nancy J. Fischbein
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Susan Chang
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Andrew Bollen
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Sarah J. Nelson
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Michael Prados
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Mitchel S. Berger
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William P. Dillon
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Figures

  • Fig 1.
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    Fig 1.

    T2* signal intensity time curves from normal cortical and background ROIs.

  • Fig 2.
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    Fig 2.

    Box plot of mitotic index labeling (MIB-1) for each tumor shows similar mean values, indicated by the small squares for both tumor types, with a larger SD for low-grade astrocytoma. Horizontal line in box indicates median.

  • Fig 3.
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    Fig 3.

    A and B, Photomicrographs from immunohistochemistry of endothelial cell marker (CD31) in low-grade gliomas (CD31 stain; original magnification, X400). Grade II astrocytoma (A) shows minimal reactivity with CD31 antibody compared with a grade II oligogdendroglioma (B), which demonstrates strong reactivity as shown by the brown staining of the vasculature.

  • Fig 4.
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    Fig 4.

    Case of a 40-year-old man with a grade II oligodendroglioma.

    A and B, Axial contrast-enhanced T1-weighted (A) and FLAIR (B) MR images demonstrate a heterogeneously enhancing (black arrows), infiltrative, cortically based mass (white arrows) in the left medial superior frontal lobe.

    C, Relative CBV map of the tumor shows a large focus of increased blood volume (arrow) in the tumor.

  • Fig 5.
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    Fig 5.

    Case of a 32-year-old man with a grade II astrocytoma.

    A and B, Axial contrast-enhanced T1-weighted (A) and FLAIR (B) MR images demonstrate a minimally enhancing (black arrows), heterogeneous T2 hyperintense mass (white arrows) in the left deep frontal white matter.

    C, Relative CBV map of the tumor shows minimally elevated blood volume in the tumor (arrow).

  • Fig 6.
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    Fig 6.

    Box plot of rCBVmax for each tumor shows a significant difference in mean rCBVmax values (small squares) between low-grade oligodendroglioma and low-grade astrocytoma, with a larger SD for low-grade oligodendroglioma. Horizontal line in box indicates median.

  • Fig 7.
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    Fig 7.

    Multiple voxels of T2* signal intensity time curves in a left superior frontal oligodendroglioma (same patient as in Fig 4) demonstrate more pronounced signal intensity decrease within the tumor (lighter shaded area) when compared with the contralateral gray matter (darker shaded area).

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American Journal of Neuroradiology: 26 (2)
American Journal of Neuroradiology
Vol. 26, Issue 2
1 Feb 2005
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Cite this article
Soonmee Cha, Tarik Tihan, Forrest Crawford, Nancy J. Fischbein, Susan Chang, Andrew Bollen, Sarah J. Nelson, Michael Prados, Mitchel S. Berger, William P. Dillon
Differentiation of Low-Grade Oligodendrogliomas from Low-Grade Astrocytomas by Using Quantitative Blood-Volume Measurements Derived from Dynamic Susceptibility Contrast-Enhanced MR Imaging
American Journal of Neuroradiology Feb 2005, 26 (2) 266-273;

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Differentiation of Low-Grade Oligodendrogliomas from Low-Grade Astrocytomas by Using Quantitative Blood-Volume Measurements Derived from Dynamic Susceptibility Contrast-Enhanced MR Imaging
Soonmee Cha, Tarik Tihan, Forrest Crawford, Nancy J. Fischbein, Susan Chang, Andrew Bollen, Sarah J. Nelson, Michael Prados, Mitchel S. Berger, William P. Dillon
American Journal of Neuroradiology Feb 2005, 26 (2) 266-273;
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Cited By...

  • SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors
  • Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making
  • 3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas
  • Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas
  • Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas
  • The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: An 11C-(R)PK11195 PET Imaging and Neuropathology Study
  • Semi-automated and automated glioma grading using dynamic susceptibility-weighted contrast-enhanced perfusion MRI relative cerebral blood volume measurements
  • Imaging Characteristics of Oligodendrogliomas That Predict Grade
  • Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours
  • Biology, genetics and imaging of glial cell tumours
  • Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study
  • Enhancing Fraction in Glioma and Its Relationship to the Tumoral Vascular Microenvironment: A Dynamic Contrast-Enhanced MR Imaging Study
  • Spin-Echo Echo-Planar Perfusion MR Imaging in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Distinguishing Solitary Metastases from Primary Glioma
  • Low-grade gliomas in adults.
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