Article Figures & Data
Figures
- Fig 1.
Sections for data analysis and corresponding MRSI sections. Central five sections (numbered 3–7) selected for data analysis in the 140-mm-thick slab over which the MRSI acquisition was carried out.
- Fig 2.
A–F, MR images corresponding to the full thickness of each MRSI section (C and D are the same), with overlays indicating the 25 regions used for data analysis.
- Fig 3.
Mean regional NAA/Cho ratios of control (black) and TBI (gray) subjects. Numbers above each histogram pair refer to regions identified in Figure 2; multiple numbers indicate that data from the regions were grouped. Average SD for control and TBI subjects were 16.7% and 16.3%, respectively.
- Fig 4.
Mean global metabolite ratios in subjects with TBI (open symbols) plotted against GCS score at admission. Horizontal lines and solid symbols indicate ratios for controls, and error bars show 2 SD. Triangles, circles, and diamonds indicate NAA/Cho, NAA/Cr, and Cho/Cr ratios, respectively.
- Fig 5.
Mean global metabolite ratios in TBI subjects obtained shortly after injury plotted against GOS scores at discharge (open symbols) and at 6 months after injury (solid symbols). Data are separated according to moderate (M) and good (G) outcomes. NAA/Cr (circles), Cho/Cr (diamonds), and NAA/Cho (triangles) ratios are indicated. Horizontal lines indicate ratios for controls, and error bars show 2 SD.
Tables
Subject/Age (yr)/Sex Admission GCS Score Time to MR Imaging (days) Cause of Injury* CT and MR Findings† 1/21/M 14 2 Skateboard accident L frontal SDH, L posterior SAH, L parietal parenchymal contusion 2/25/M 15 8 Skateboard accident R parietal occipital skull fx, R tentorial SDH, pneumocephalus 3/53/F 15 24 MVA Normal 4/41/M 15 3 Bike vs auto accident R temporal and R frontal mild cerebral contusion 5/36/F 14 11 Ped vs auto accident Diffuse SAH, L ear laceration 6/37/M 15 7 Ped vs auto accident Midline SDH 7/31/M 14 6 MVA Normal 8/36/M 14 14 Bike vs auto accident Normal 9/18/F 15 8 MVA Normal 10/22/M 14 24 MVA Small L SDH 11/22/M 13 23 MVA R SAH, L SDH, L noncompressed temporal skull fx 12/49/F 15 12 Fall SAH at interhemispheric astula, frontal brain contusion 13/25/M 14 14 Ped vs auto accident L frontal SAH, R SDH 14/28/M 14 30 Assault L frontotemporal SDH, R SDH, bilateral temporal and L frontal contusion * MVA indicates motor vehicle accident; Ped, pedestrian.
† fx indicates fracture; SAH, subarachnoid hematoma; SDH, subdural hematoma.
Region NAA/Cr Cho/Cr NAA/Cho Control TBI Control TBI Control TBI 5 1.41 (0.23) 1.41 (0.27) 0.66 (0.07) 0.73 (0.08)* 2.17 (0.37) 1.94 (0.41) 10 1.75 (0.19) 1.67 (0.14) 0.72 (0.10) 0.77 (0.10) 2.47 (0.41) 2.21 (0.24)* 12 1.72 (0.19) 1.60 (0.11) 0.70 (0.11) 0.78 (0.15) 2.48 (0.38) 2.11 (0.38)* 13 1.57 (0.23) 1.53 (0.23) 0.55 (0.06) 0.63 (0.09)* 2.89 (0.60) 2.50 (0.51) 16 1.85 (0.16) 1.72 (0.12)* 0.86 (0.12) 0.80 (0.11) 2.19 (0.30) 2.18 (0.37) 19 1.86 (0.17) 1.70 (0.12)* 0.90 (0.11) 0.86 (0.10) 2.10 (0.27) 2.00 (0.21) 20 1.84 (0.17) 1.73 (0.14) 0.70 (0.09) 0.74 (0.12) 2.67 (0.35) 2.37 (0.33)* 21 1.71 (0.18) 1.62 (0.13) 0.56 (0.09) 0.60 (0.07) 3.11 (0.47) 2.74 (0.43)* Note.—Data are the mean (SD) and were obtained from eight regions across three contiguous MRSI sections of 15-mm thickness.
* P < .05
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