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Research ArticleBrain

Functional MR Imaging Study of Language-Related Differences in Bilingual Cerebellar Activation

Jay J. Pillai, Jerry D. Allison, Sankar Sethuraman, Julio M. Araque, Dharma Thiruvaiyaru, Claro B. Ison, David W. Loring and Thomas Lavin
American Journal of Neuroradiology April 2004, 25 (4) 523-532;
Jay J. Pillai
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Jerry D. Allison
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Sankar Sethuraman
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Julio M. Araque
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Dharma Thiruvaiyaru
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Claro B. Ison
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David W. Loring
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Thomas Lavin
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  • Fig 1.
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    Fig 1.

    Four sets of orthogonal SPM99 glass-brain MIP images depict the normalized group-averaged results of all eight individuals (P = .001, 10-voxel clustering threshold). On the coronal images, the left side represents the left hemisphere. On the axial images, the left side is posterior, and the lower half represents the right hemisphere.

    A, Spanish noun-verb task subtracted from the English noun-verb task.

    B, Spanish phonological task subtracted from the English phonological task.

    C, English noun-verb task subtracted from the Spanish noun-verb task.

    D, English phonological task subtracted from the Spanish phonological task.

  • Fig 2.
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    Fig 2.

    Combined (phonological and noun-verb) task subtractions. Orthogonal glass-brain MIP images display group-averaged normalized results (P < .001, 10-voxel clustering threshold).

    A, English minus Spanish.

    B, Spanish minus English.

  • Fig 3.
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    Fig 3.

    Group-averaged normalized data for all eight subjects. Activated voxels are overlaid on standard T1-weighted axial anatomic images, which demonstrate the difference in lateralization between the tasks, with greater left lateralization in the English task. The datasets were normalized to the standard MNI space within SPM99. Top row, Spanish noun-verb task. Bottom row, English noun-verb task.

  • Fig 4.
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    Fig 4.

    Combined tasks. These results are essentially based on a single sample t test based on a consideration of individual normalized data for each of the two tasks (P < .001 with 10-voxel clustering).

    A, Combined English tasks versus control.

    B, Combined Spanish tasks versus control.

  • Fig 5.
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    Fig 5.

    Anatomic MPRAGE images show the functional data overlays on the anatomic sections through the cerebellum. The results from Figure 4A (top) and B (bottom) are depicted. The right side of each image is the anatomic left side, and the left side of each image, the anatomic right side.

  • Fig 6.
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    Fig 6.

    Anatomic overlays of the group-averaged normalized combined English task and combined Spanish task functional data on supratentorial anatomic MPRAGE sections. Functional data from Figure 5 are shown (P < .001 with 10 voxel clustering).

Tables

  • Figures
  • Cerebellar ROI fMRI activation data

    TaskVoxel CountLeft ROIRight ROI
    Coordinates of Voxel with Maximal T ValueMaximal T ValueModified Voxel CountCoordinates of Voxel with Maximal T ValueMaximal T ValueModified Voxel Count
    LeftRightxyzxyz
    Subject A
     ENG NnVb368169−34−84−288.611996−78−387.0251
     ENG Phono403100−40−62−268.112568−76−285.3122
     SPN NnVb15568−32−84−266.758518−80−404.8530
     SPN Phono1940−40−60−266.3115700
    Subject B
     ENG NnVb12231078−40−76−2217.81108436−74−2011.9669
     ENG Phono11751018−40−68−1815.55106738−74−2610.31683
     SPN NnVb387186−38−76−2012.5927228−82−285.3321
     SPN Phono383210−28−82−2011.8935736−74−166.59210
    Subject C
     ENG NnVb14855−28−70−225.795012−74−244.3126
     ENG Phono18559−48−58−306.857418−54−124.966
     SPN NnVb24087−18−58−125.662640−52−224.5336
     SPN Phono8643−40−76−304.883134−70−264.4714
    Subject D
     ENG NnVb542414−26−84−329.2335926−84−2611.25276
     ENG Phono309426−24−86−347.2326228−84−2611.91223
     SPN NnVb22732−42−74−266.2813944−60−204.125
     SPN Phono46131−42−76−244.252924−84−256.92110
    Subject E
     ENG NnVb402115−36−52−307.9438816−78−244.992
     ENG Phono346163−36−78−229.0617222−76−264.85117
     SPN NnVb16713−34−76−245.999926−80−324.5313
     SPN Phono8718−46−66−245.082214−82−243.917
    Subject F
     ENG NnVb10−42−48−243.64100
     ENG Phono285248−36−64−306.5512422−74−206.69175
     SPN NnVb120118−38−48−325.457740−74−226.4671
     SPN Phono10−42−48−243.64100
    Subject G
     ENG NnVb985448−44−64−2610.5684020−80−508.0263
     ENG Phono401391−46−58−267.3632738−76−367.27110
     SPN NnVb7112−46−58−265.33386−76−32412
     SPN Phono9026−46−60−284.988640−58−244.2123
    Subject H
     ENG NnVb233118−38−80−245.7120616−74−404.7476
     ENG Phono338112−42−74−246.7231020−72−365.8483
     SPN NnVb279139−46−66−265.6815028−74−306.0773
     SPN Phono170−42−66−224.611700
    • Note.—ENG = English, SPN = Spanish, NnVb = noun-verb association task, Phono = phonological task.

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American Journal of Neuroradiology: 25 (4)
American Journal of Neuroradiology
Vol. 25, Issue 4
1 Apr 2004
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Cite this article
Jay J. Pillai, Jerry D. Allison, Sankar Sethuraman, Julio M. Araque, Dharma Thiruvaiyaru, Claro B. Ison, David W. Loring, Thomas Lavin
Functional MR Imaging Study of Language-Related Differences in Bilingual Cerebellar Activation
American Journal of Neuroradiology Apr 2004, 25 (4) 523-532;

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Functional MR Imaging Study of Language-Related Differences in Bilingual Cerebellar Activation
Jay J. Pillai, Jerry D. Allison, Sankar Sethuraman, Julio M. Araque, Dharma Thiruvaiyaru, Claro B. Ison, David W. Loring, Thomas Lavin
American Journal of Neuroradiology Apr 2004, 25 (4) 523-532;
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