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OtherPediatric Neuroimaging

Metachromatic Leukodystrophy: Diffusion MR Imaging Findings

R. Nuri Sener
American Journal of Neuroradiology September 2002, 23 (8) 1424-1426;
R. Nuri Sener
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    Fig 1.

    Images obtained at initial examination, performed when the patient was 10 months old.

    A, T2-weighted image reveals hyperintense changes in the deep white matter and atrophy.

    B, A b = 1000 mm2/s (heavily diffusion-weighted) image from an echo-planar trace sequence reveals hyperintense changes similar to those of cytotoxic edema.

    C, Corresponding ADC map reveals a low signal intensity and low ADC value (0.55 × 10−3 mm2/s) in the deep white matter compared with the peripheral regions of the parenchyma, including peripheral white matter and the cortex (0.95 × 10−3 mm2/s).

  • Fig 2.
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    Fig 2.

    Images obtained during follow-up, when the patient was 16 months old.

    A, A b = 1000 mm2/s (heavily diffusion-weighted) image from echo-planar trace sequence reveals same hyperintense lesions.

    B, Gradient-echo diffusion sequence (reverse fast imaging in steady-state precession) reveals high signal intensity and high pixel values (165) in the deep white matter, compared with the peripheral regions of the parenchyma (99).

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American Journal of Neuroradiology: 23 (8)
American Journal of Neuroradiology
Vol. 23, Issue 8
1 Sep 2002
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R. Nuri Sener
Metachromatic Leukodystrophy: Diffusion MR Imaging Findings
American Journal of Neuroradiology Sep 2002, 23 (8) 1424-1426;

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Metachromatic Leukodystrophy: Diffusion MR Imaging Findings
R. Nuri Sener
American Journal of Neuroradiology Sep 2002, 23 (8) 1424-1426;
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Cited By...

  • Toward a Better Understanding of Brain Lesions during Metachromatic Leukodystrophy Evolution
  • Sporadic leucodystrophy with neuroaxonal spheroids: persistence of DWI changes and neurocognitive profiles: a case study
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