Article Figures & Data
Figures
- Fig 1.
Images in patient 4.
A and B, Contrast-enhanced T1-weighted volume images. In B, the solid arrow indicates a region of an enhancing tumor margin; dashed arrow, enhancing tumor core; dotted arrow, nonenhancing tumor core.
C and D, T2-weighted EP images. Arrow in D indicates a region of edematous brain.
E, 〈D〉 parametric map.
F, FA parametric map.
- Fig 2.
Images in patient 5.
A, Contrast-enhanced T1-weighted volume image. The solid arrow indicates a region of enhancing tumor margin; dashed arrow, enhancing tumor core; dotted arrow, nonenhancing tumor core.
B, T2-weighted EP images. Arrow indicates a region of edematous brain.
C and D, Note the high 〈D〉 and low FA values in the nonenhancing tumor core and edematous brain on the 〈D〉 parametric map (C) and FA parametric map (D).
- Fig 3.
Images in patient 3. The thick arrow indicates a region of enhancing tumor margin; the thin arrow in B indicates edematous brain.
A, Contrast-enhanced T1-weighted volume image.
B, T2-weighted EP images.
C, 〈D〉 parametric map. Note the diffuse nature of the edema.
D, FA parametric map.
Tables
- TABLE 1:
TABLE 1: 〈D〉 values in the neoplasm, surrounding edematous brain, and normal white matter in nine patients with high-grade glioma
Patient/Age (y)/Sex Mean 〈D〉 Value (× 10−6 mm2/s) Enhancing Tumor Margin Enhancing Tumor Core Nonenhancing Tumor Core Edematous Brain Normal White Matter Ipsilateral Contralateral 1/61/F* 958.69 ± 64.28 NA NA 1127.17 ± 155.62 725.53 ± 16.08 720.90 ± 37.18 2/43/M*† 948.56 ± 52.35 NA NA 923.87 ± 60.71 747.34 ± 1.43 731.76 ± 11.34 3/56/F*‡ 928.34 ± 50.88 NA NA 1221.99 ± 261.25 NA NA 4/65/M 1238.54 ± 158.93 1500.83 ± 275.19 1861.26 ± 292.52 1494.35 ± 210.91 717.50 ± 23.28 704.44 ± 19.58 5/71/M 1195.37 ± 206.51 1181.63 ± 294.64 1890.93 ± 275.34 1477.25 ± 279.53 753.10 ± 50.43 774.64 ± 63.37 6/50/M 1289.65 ± 227.58 1571.22 ± 108.36 1784.93 ± 301.46 1575.23 ± 215.07 745.16 ± 25.87 735.33 ± 29.34 7/42/M 1208.40 ± 170.22 1256.69 ± 213.05 1264.92 ± 395.20 1143.00 ± 326.96 739.16 ± 21.58 720.83 ± 18.43 8/55/F 1185.35 ± 262.88 1031.14 ± 326.10 NA 1674.29 ± 253.11 725.90 ± 27.08 715.58 ± 34.79 9/74/M§ 1309.58 ± 142.09 1356.45 ± 225.76 1957.34 ± 424.16 1565.69 ± 219.01 NA 768.67 ± 9.05 Mean 1229.80 ± 206.80 1308.67 ± 292.50 1825.38 ± 404.06 1411.23 ± 322.31 733.51 ± 31.59 730.00 ± 37.69 Note.—All values are reported as the mean ± the standard deviation. Normal white matter was the centrum semiovale. NA indicates not applicable.
* This patient had a multifocal glioma.
† This patient had a low-grade glioma with a malignant core.
‡ T2-weighted EP images depicted abnormal signal intensity throughout the ipsilateral and contralateral centrum semiovale.
§ T2-weighted EP images depicted abnormal signal intensity throughout the ipsilateral centrum semiovale.
- TABLE 2:
TABLE 2: FA values in the neoplasm, surrounding edematous brain, and normal white matter in nine patients with high-grade glioma
Patient FA Value Enhancing Tumor Margin Enhancing Tumor Core Nonenhancing Tumor Core Edematous Brain Normal White Matter Ipsilateral Contralateral 1* 0.20 ± 0.06 NA NA 0.21 ± 0.07 0.51 ± 0.02 0.42 ± 0.07 2*† 0.22 ± 0.04 NA NA 0.23 ± 0.08 0.50 ± 0.04 0.47 ± 0.11 3*‡ 0.18 ± 0.06 NA NA 0.17 ± 0.07 NA NA 4 0.16 ± 0.07 0.10 ± 0.03 0.07 ± 0.01 0.14 ± 0.05 0.43 ± 0.10 0.48 ± 0.06 5 0.15 ± 0.05 0.14 ± 0.06 0.08 ± 0.02 0.18 ± 0.09 0.47 ± 0.07 0.52 ± 0.07 6 0.13 ± 0.03 0.08 ± 0.03 0.07 ± 0.01 0.15 ± 0.05 0.45 ± 0.09 0.51 ± 0.05 7 0.18 ± 0.05 0.15 ± 0.07 0.10 ± 0.03 0.25 ± 0.10 0.44 ± 0.10 0.46 ± 0.09 8 0.20 ± 0.05 0.14 ± 0.04 NA 0.15 ± 0.06 0.48 ± 0.08 0.48 ± 0.08 9§ 0.18 ± 0.06 0.13 ± 0.05 0.10 ± 0.03 0.17 ± 0.06 NA 0.46 ± 0.02 Mean 0.16 ± 0.06 0.13 ± 0.06 0.09 ± 0.03 0.17 ± 0.08 0.46 ± 0.08 0.48 ± 0.08 Note.—All values are reported as the mean ± the standard deviation. Normal white matter was the centrum semiovale. NA indicates not applicable.
* This patient had a multifocal glioma.
† This patient had a low-grade glioma with a malignant core.
‡ T2-weighted EP images depicted abnormal signal intensity throughout the ipsilateral and contralateral centrum semiovale.
§ T2-weighted EP images depicted abnormal signal intensity throughout the ipsilateral centrum semiovale.
- TABLE 3:
TABLE 3: Statistical analysis of differences in 〈D〉 and FA values in nine patients with high-grade glioma
Comparison Patients with a Statistically Significant Difference* 〈D〉 Value FA Edematous brain versus enhancing tumor margin 1–9 1, 4–9 Ipsilateral white matter versus enhancing tumor margin 1, 2, 4–9 1, 2, 4–9 Ipsilateral white matter versus edematous brain 1, 2, 4–9 1, 2, 4–9 Note.—In patient 3, T2-weighted EP images depicted abnormal signal intensity throughout the ipsilateral and contralateral centrum semiovale. In patient 9, T2-weighted EP images depicted abnormal signal intensity throughout ipsilateral centrum semiovale. Data in the contralateral centrum semiovale were used in this analysis.
* P < .05, post hoc Scheffé test.
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