Article Figures & Data
Figures
- fig 1.
A–C. T2-weighted MR images at 3000/100/1 (TR/TE/excitation) at the following times after initial symptom (headache) onset. A, At 14 days, bilateral thalamic lesions (left slightly more prominent than right). B, At 21 days, thalamic lesions have increased in size and new lesion has appeared in left cerebral peduncle (lesions in left globus pallidus and forceps major not shown). C, At 32 days, further progression of thalamic lesions to involve right geniculate body, right posterior limb of internal capsule, and complete involvement of left putamen and globus pallidus tracking down to left cerebral peduncle (bilateral lesions in hemispheric white matter and left frontoparietal cortex not shown)
- fig 1.
D–F. D, At 8 weeks, pattern of involvement dramatically changed, with resolution of lesions in thalami and left cerebral peduncle, and with new lesions in left caudatum, putamen, and globus pallidus, and in right globus pallidus, anterior thalamus, cerebral peduncle, and posterior limb of internal capsule. (Hyperintensity of subcortical white matter of right temporal lobe not shown.) E, At 17 weeks, nearly all lesions resolved, with only minimal hyperintensity of left caudate nucleus and frontal periventricular white matter (not shown). F, At 25 weeks, all T2 hyperintense lesions completely resolved
- fig 2.
Proton MRSI at 8 (top) and 25 (bottom) weeks after initial symptom onset. Localizer T1-weighted MR images at 300/13/1 (TR/TE/excitation) and metabolic images at 2300/280/1 (TR/TE/excitation) of choline and NAA from the second of four sections shown. Selected spectrum from left caudatum shown at both time points (voxel location indicated on T1-weighted images). At 8 weeks, NAA image shows decreased levels in left caudatum, lenticular nuclei, and right internal capsule, corresponding to lesions seen in T2-weighted MR images (fig 1D). Choline signals within normal limits; note high choline signal in thalamic region is normal for these regions (Table 2). By 25 weeks, NAA recovered to normal levels in all these regions, whereas creatine and choline levels remain stable (Table 2)
Tables
TABLE 1:CSF white and red blood cell counts and protein and glucose levels
- TABLE 2:
Metabolite concentrations (mM) in selected brain structures at 8 and 25 weeks after first onset of symptoms, and ratios of metabolite levels at 25 and 8 weeks (% increase or decrease)
