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Research ArticleBrain

Regional Differences and Metabolic Changes in Normal Aging of the Human Brain: Proton MR Spectroscopic Imaging Study

Emmanuelle Angelie, Alain Bonmartin, Abdel Boudraa, Pierre-Marie Gonnaud, Jean-Jacques Mallet and Dominique Sappey-Marinier
American Journal of Neuroradiology January 2001, 22 (1) 119-127;
Emmanuelle Angelie
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Alain Bonmartin
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Abdel Boudraa
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Pierre-Marie Gonnaud
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Jean-Jacques Mallet
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Dominique Sappey-Marinier
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    fig 1. MR images identify the position of the PRESS volumes centered at the centrum semiovale and temporal lobe.

    A, Sagittal T1-weighted MR image shows the PRESS volume (large box) localized at the centrum semiovale.

    B, Sagittal T1-weighted MR image shows the PRESS volume (large box) localized in the temporal lobe.

    C, Axial T2-weighted MR image shows the PRESS volume (large box) localized at the centrum semiovale. For metabolite quantitation, 30 voxels were selected and registered on the corresponding MR spectroscopic images. Markers indicate the positions of individual voxels selected in the cortical (x) and semioval (o) regions.

    D, Axial T2-weighted MR image shows the PRESS volume (large box) localized in the temporal lobe. For metabolite quantitation, 30 voxels were selected and registered on the corresponding MR spectroscopic images. Markers indicate the positions of individual voxels selected in the temporal (x) and hippocampal (o) regions.

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    fig 2.

    Spectroscopic images of NAA obtained from the brain of a young participant. Four representative 1H MR spectra (C1–C4) were selected from the voxels (voxels 1–4) in the cortical (C1), semioval (C2), hippocampal (C3), and temporal (C4) regions to illustrate the regional variations. The nominal size (0.8 × 0.8 × 2 cm3) of the individual voxels is shown on the MRS images.

    A, Localized at the centrum semiovale.

    B, Localized in the temporal lobe.

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    fig 3.

    Regression plots of %NAA, %Cr, and %Cho in the semioval region regarding age

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    TABLE 1:

    Rates (in % of decade) and correlation coefficients (r) of the linear regressions calculated between the metabolite ratios in four cerebral regions and the age of the subjects

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    TABLE 2:

    Metabolite ratios (Mean ± SD) in four cerebral regions and two age groups

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American Journal of Neuroradiology
Vol. 22, Issue 1
1 Jan 2001
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Cite this article
Emmanuelle Angelie, Alain Bonmartin, Abdel Boudraa, Pierre-Marie Gonnaud, Jean-Jacques Mallet, Dominique Sappey-Marinier
Regional Differences and Metabolic Changes in Normal Aging of the Human Brain: Proton MR Spectroscopic Imaging Study
American Journal of Neuroradiology Jan 2001, 22 (1) 119-127;

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Regional Differences and Metabolic Changes in Normal Aging of the Human Brain: Proton MR Spectroscopic Imaging Study
Emmanuelle Angelie, Alain Bonmartin, Abdel Boudraa, Pierre-Marie Gonnaud, Jean-Jacques Mallet, Dominique Sappey-Marinier
American Journal of Neuroradiology Jan 2001, 22 (1) 119-127;
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