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Research ArticleBrain

Demyelinating Plaques in Relapsing-remitting and Secondary-progressive Multiple Sclerosis: Assessment with Diffusion MR Imaging

Alessandro Castriota Scanderbeg, Francesco Tomaiuolo, Umberto Sabatini, Ugo Nocentini, Maria G. Grasso and Carlo Caltagirone
American Journal of Neuroradiology May 2000, 21 (5) 862-868;
Alessandro Castriota Scanderbeg
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Francesco Tomaiuolo
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Umberto Sabatini
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Ugo Nocentini
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Maria G. Grasso
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Carlo Caltagirone
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    fig 1.

    A–D, Axial SE T1-weighted (A), fast SE T2-weighted (B), and echo-planar T2-weighted (C) MR images, and the orientationally averaged ADC map (D), show the presence of multiple periventricular demyelinating lesions in a patient with secondary-progressive MS. Circle indicates the ROI

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    fig 2.

    Scatter plot of the coefficient <D> data points for the relapsing-remitting (RR, 10 points), secondary-progressive (SP, 10 points), and control group (NWM, normal white matter, 11 points). Each point corresponds to one subject and represents the mean value of <D> as obtained in each subject from all the ROIs that were drawn on the T2-weighted (b = 0) images. Graph shows there is no overlap between the relapsing-remitting and secondary-progressive groups

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    fig 3.

    Scatter plot of the coefficient <D> vs. EDSS score shows a significant correlation. Each point corresponds to one patient and represents the mean value of <D> as obtained from all the ROIs that were drawn on the T2-weighted (b = 0) images. Closed circles represent the subjects with relapsing-remitting MS; open circles, the subjects with secondary-progressive MS

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    fig 4.

    Scatter plot of coefficient <D> vs. disease duration shows a significant correlation. Each point corresponds to one patient and represents the mean value of <D> as obtained from all the ROIs that were drawn on the T2-weighted (b = 0) images. Closed circles represent the patients with relapsing-remitting MS; open circles, the patients with secondary-progressive MS

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    fig 5.

    Scatter plot of coefficient <D> vs. SIlesion/SICSF ratio on SE T1-weighted images for the 41 T1 hypointense lesions studied. There is a significant inverse correlation between <D> and SIlesion/SICSF ratio. Each point corresponds to one lesion. Closed circles represent lesions from the relapsing-remitting group (11 lesions); open circles, lesions from the secondary-progressive group (30 lesions)

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American Journal of Neuroradiology
Vol. 21, Issue 5
1 May 2000
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Alessandro Castriota Scanderbeg, Francesco Tomaiuolo, Umberto Sabatini, Ugo Nocentini, Maria G. Grasso, Carlo Caltagirone
Demyelinating Plaques in Relapsing-remitting and Secondary-progressive Multiple Sclerosis: Assessment with Diffusion MR Imaging
American Journal of Neuroradiology May 2000, 21 (5) 862-868;

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Demyelinating Plaques in Relapsing-remitting and Secondary-progressive Multiple Sclerosis: Assessment with Diffusion MR Imaging
Alessandro Castriota Scanderbeg, Francesco Tomaiuolo, Umberto Sabatini, Ugo Nocentini, Maria G. Grasso, Carlo Caltagirone
American Journal of Neuroradiology May 2000, 21 (5) 862-868;
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  • Analysis of Normal-Appearing White Matter in Multiple Sclerosis: Comparison of Diffusion Tensor MR Imaging and Magnetization Transfer Imaging
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