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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

MR Spectroscopy in Gliomatosis Cerebri

Martin Bendszus, Monika Warmuth-Metz, Rüdiger Klein, Ralf Burger, Christian Schichor, Jörg C. Tonn and Laszlo Solymosi
American Journal of Neuroradiology February 2000, 21 (2) 375-380;
Martin Bendszus
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Monika Warmuth-Metz
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Rüdiger Klein
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Ralf Burger
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Christian Schichor
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Jörg C. Tonn
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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Laszlo Solymosi
aFrom the Departments of Neuroradiology (M.B., M.W-M., L.S.), Neuropathology (R.K.), and Neurosurgery (R.B., C.S., J.C.T.), University of Würzburg, Germany.
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    fig 1.

    Case 4: 38-year-old woman with bifrontal hyperintensity and tumor spread via corpus callosum.

    A, Axial T2-weighted spin-echo localizer image (1900/80).

    B, Corresponding spectrum (CSI, PRESS, 1500/135, voxel size = 7.5 × 7.5 × 15 mm) shows a moderate increase in Cho/Cr and Cho/NAA and a decrease in NAA/Cr.

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    fig 2.

    Case 5: 12-year-old boy with seizure.

    A, Axial T1-weighted localizer image (fast low-angle shot, 80/10) shows extensive hypointense infiltration of the right hemisphere with little mass effect.

    B, Corresponding spectrum (CSI, PRESS, 1500/135, voxel size = 7.5 × 7.5 × 15 mm) shows a marked increase in Cho/Cr and Cho/NAA and a pronounced decrease in NAA/Cr. Moreover, there is a lactate doublet at 1.35 ppm.

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    fig 3.

    Case 8: 55-year-old man with diffuse involvement of both hemispheres.

    A, Axial T2-weighted spin-echo localizer image (1900/80).

    B, Corresponding spectrum. Stereotactic biopsy sample was taken from the denoted voxel, with a maximum Cho/NAA ratio of the lesion of 8.9 as well as a lactate doublet at 1.35 ppm. Histopathologic examination revealed a grade IV tumor. In other areas of the tumor there were lipid signals at 0.8 to 1.3 ppm (CSI, PRESS, 1500/135, voxel size = 7.5 × 7.5 × 15 mm).

    fig 4. Case 1: 10-year-old boy with seizure. Axial spin-echo T2-weighted image (1900/80) shows extensive hyperintensity of the left occipital, parietal, and temporal lobes, with infiltration of the thalamus and the insula. Both gray and white matter are affected, and there is little mass effect

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    fig 5.

    Metabolite ratios for Cho/Cr, NAA/Cr, and Cho/NAA. The difference between the histopathologic tumor grades is most pronounced in the Cho/NAA ratio. In the group of low-grade lesions, the maximum Cho/NAA level is 1.3, whereas in anaplastic tumors, the Cho/NAA ratio is at least 2.5 with a maximum value of 8.9 in a grade IV lesion

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    Data for eight patients with gliomatosis cerebri

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American Journal of Neuroradiology
Vol. 21, Issue 2
1 Feb 2000
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Cite this article
Martin Bendszus, Monika Warmuth-Metz, Rüdiger Klein, Ralf Burger, Christian Schichor, Jörg C. Tonn, Laszlo Solymosi
MR Spectroscopy in Gliomatosis Cerebri
American Journal of Neuroradiology Feb 2000, 21 (2) 375-380;

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MR Spectroscopy in Gliomatosis Cerebri
Martin Bendszus, Monika Warmuth-Metz, Rüdiger Klein, Ralf Burger, Christian Schichor, Jörg C. Tonn, Laszlo Solymosi
American Journal of Neuroradiology Feb 2000, 21 (2) 375-380;
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