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Research ArticleORIGINAL RESEARCH

Mapping fetal brain development of 10 weeks gestational age with 9.4T postmortem MRI and histological sections

Z. Zhang, Y. Gao, X. Lin, X. He, X. Wang and S. Liu
American Journal of Neuroradiology December 2024, ajnr.A8595; DOI: https://doi.org/10.3174/ajnr.A8595
Z. Zhang
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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Y. Gao
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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X. Lin
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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X. He
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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X. Wang
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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S. Liu
From the Department of Medical Imaging (Z.Z., X.W.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Radiology (G.Y.), Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China; Research Center for Sectional and Imaging Anatomy (X.L., S.L.), Shandong University Cheeloo College of Medicine, Jinan, Shandong, China; Department of Imaging (H.X.), Heze Penoy people's Hospital, Heze, Shandong, China.
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ABSTRACT

BACKGROUND AND PURPOSE: The 10th week of gestational age (GA) is a critical period for evaluating brain development, but there is limited knowledge regarding the specific characteristics at this GA. This study is to map the brain structures at 10 weeks GA using 9.4T MRI and histological sections.

MATERIALS AND METHODS: Six fetal specimens with normal brain development were imaged using 9.4T MRI, followed by sectioning and staining. The three-dimensional (3D) reconstruction models and quantitative measurements were obtained with Amira software.

RESULTS: Four zones of the laminar organization were identified in T2-weighted MRIs, while six zones were delineated in the corresponding histological sections, demonstrating a strong consistency between the two. The key structures, including the midline structures, choroid plexus, subcortical nuclei, ventricles, brainstem, and cerebellum, were clearly distinguishable with unique characteristics in both MRIs and histological sections. The 3D visualization model effectively demonstrated the shape, spatial positions, and interrelationships of the early fetal brain structures, and their qualitative measurements were obtained. The lateral ventricles and choroid plexus constituted a substantial proportion, with the lateral ventricles accounting for 43.0% of the cerebral hemisphere and the choroid plexus comprising 41.2% of the lateral ventricles.

CONCLUSIONS: At 10 weeks GA, the fetal brain is in an early developmental stage. The integration of 9.4T T2-weighted MRIs, 3D reconstruction, and histological sections offers a comprehensive view of the early fetal brain's characteristics, providing valuable insights for clinicians and anatomists.

ABBREVIATIONS: GA=gestational age; 3D=three-dimensional; US=ultrasound; CNS=central nervous system; microfocus-CT=micro-CT

Footnotes

  • The authors declare no conflicts of interest related to the content of this article.

  • © 2024 by American Journal of Neuroradiology

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Cite this article
Accepted Manuscript
Z. Zhang, Y. Gao, X. Lin, X. He, X. Wang, S. Liu
Mapping fetal brain development of 10 weeks gestational age with 9.4T postmortem MRI and histological sections
American Journal of Neuroradiology Dec 2024, ajnr.A8595; DOI: 10.3174/ajnr.A8595

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Accepted Manuscript
Mapping fetal brain development of 10 weeks gestational age with 9.4T postmortem MRI and histological sections
Z. Zhang, Y. Gao, X. Lin, X. He, X. Wang, S. Liu
American Journal of Neuroradiology Dec 2024, ajnr.A8595; DOI: 10.3174/ajnr.A8595
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