More articles from Adult Brain

This is a retrospective review of the medical records of 706 consecutive patients who were treated with irradiation for primary brain tumors at The Johns Hopkins Medical Institutions between June 1995–January 2010. The authors found that the appearance of hyperintense dentate nuclei (HDN) is likely permanent, given the long follow-up time of the study, and a significant association between HDN and repeated contrast-enhanced MR studies. A significant increase in the likelihood of HDN occurred after 4 or more enhanced scans, and total dose of 77 ml of gadolinium contrast agent. They found no association between radiation exposure and HDN.