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This study of 10 patients with DPG showed characteristic thickening of the ventral hypothalamic midline and duplication of the infundibulum, as well as associated craniofacial dysraphism, oropharyngeal mass (ie, teratoma), and vascular and vertebral anomalies. The repetitive spectrum of ventral abnormalities involving the skull base, pituitary region, corpus callosum, tuber cinereum, brainstem, cerebral arteries, and cervical spine suggests axial mesoderm duplication.