Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Presurgical Identification of Primary Central Nervous System Lymphoma with Normalized Time-Intensity Curve: A Pilot Study of a New Method to Analyze DSC-PWI

A. Pons-Escoda, A. Garcia-Ruiz, P. Naval-Baudin, M. Cos, N. Vidal, G. Plans, J. Bruna, R. Perez-Lopez and C. Majos
American Journal of Neuroradiology October 2020, 41 (10) 1816-1824; DOI: https://doi.org/10.3174/ajnr.A6761
A. Pons-Escoda
aRadiology Department (A.P.-E., P.N.-B., M.C., C.M.), Institut de Diagnòstic per la Imatge, Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat, Barcelona, Spain
fNeurooncology Unit (A.P.-E., N.V., G.P., J.B., C.M.), Insitut Català d’Oncologia, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Pons-Escoda
A. Garcia-Ruiz
bRadiomics Group (A.G.-R., R.P.-L.), Vall d’Hebron Institut d’Oncologia, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Garcia-Ruiz
P. Naval-Baudin
aRadiology Department (A.P.-E., P.N.-B., M.C., C.M.), Institut de Diagnòstic per la Imatge, Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Naval-Baudin
M. Cos
aRadiology Department (A.P.-E., P.N.-B., M.C., C.M.), Institut de Diagnòstic per la Imatge, Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Cos
N. Vidal
cPathology Department (N.V.), Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
fNeurooncology Unit (A.P.-E., N.V., G.P., J.B., C.M.), Insitut Català d’Oncologia, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Vidal
G. Plans
dNeurosurgery Department (G.P.), Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
fNeurooncology Unit (A.P.-E., N.V., G.P., J.B., C.M.), Insitut Català d’Oncologia, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Plans
J. Bruna
eNeurology Department (J.B.), Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
fNeurooncology Unit (A.P.-E., N.V., G.P., J.B., C.M.), Insitut Català d’Oncologia, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Bruna
R. Perez-Lopez
bRadiomics Group (A.G.-R., R.P.-L.), Vall d’Hebron Institut d’Oncologia, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Perez-Lopez
C. Majos
aRadiology Department (A.P.-E., P.N.-B., M.C., C.M.), Institut de Diagnòstic per la Imatge, Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat, Barcelona, Spain
fNeurooncology Unit (A.P.-E., N.V., G.P., J.B., C.M.), Insitut Català d’Oncologia, Institut d’Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Majos
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Abstract

BACKGROUND AND PURPOSE: DSC-PWI has demonstrated promising results in the presurgical diagnosis of brain tumors. While most studies analyze specific parameters derived from time-intensity curves, very few have directly analyzed the whole curves. The aims of this study were the following: 1) to design a new method of postprocessing time-intensity curves, which renders normalized curves, and 2) to test its feasibility and performance on the diagnosis of primary central nervous system lymphoma.

MATERIALS AND METHODS: Diagnostic MR imaging of patients with histologically confirmed primary central nervous system lymphoma were retrospectively reviewed. Correlative cases of glioblastoma, anaplastic astrocytoma, metastasis, and meningioma, matched by date and number, were retrieved for comparison. Time-intensity curves of enhancing tumor and normal-appearing white matter were obtained for each case. Enhancing tumor curves were normalized relative to normal-appearing white matter. We performed pair-wise comparisons for primary central nervous system lymphoma against the other tumor type. The best discriminatory time points of the curves were obtained through a stepwise selection. Logistic binary regression was applied to obtain prediction models. The generated algorithms were applied in a test subset.

RESULTS: A total of 233 patients were included in the study: 47 primary central nervous system lymphomas, 48 glioblastomas, 39 anaplastic astrocytomas, 49 metastases, and 50 meningiomas. The classifiers satisfactorily performed all bilateral comparisons in the test subset (primary central nervous system lymphoma versus glioblastoma, area under the curve = 0.96 and accuracy = 93%; versus anaplastic astrocytoma, 0.83 and 71%; versus metastases, 0.95 and 93%; versus meningioma, 0.93 and 96%).

CONCLUSIONS: The proposed method for DSC-PWI time-intensity curve normalization renders comparable curves beyond technical and patient variability. Normalized time-intensity curves performed satisfactorily for the presurgical identification of primary central nervous system lymphoma.

ABBREVIATIONS:

AUC
area under the curve
NAWM
normal-appearing white matter
nTIC
normalized time-intensity curve
MSID
maximal signal intensity drop
PCNSL
primary central nervous system lymphoma
PSR
percentage of signal recovery
TIC
time-intensity curve
CE-T1WI
contrast-enhanced T1WI
TTA
time-to-arrival
rCBV
relative cerebral blood volume
  • © 2020 by American Journal of Neuroradiology
View Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (10)
American Journal of Neuroradiology
Vol. 41, Issue 10
1 Oct 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Presurgical Identification of Primary Central Nervous System Lymphoma with Normalized Time-Intensity Curve: A Pilot Study of a New Method to Analyze DSC-PWI
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Pons-Escoda, A. Garcia-Ruiz, P. Naval-Baudin, M. Cos, N. Vidal, G. Plans, J. Bruna, R. Perez-Lopez, C. Majos
Presurgical Identification of Primary Central Nervous System Lymphoma with Normalized Time-Intensity Curve: A Pilot Study of a New Method to Analyze DSC-PWI
American Journal of Neuroradiology Oct 2020, 41 (10) 1816-1824; DOI: 10.3174/ajnr.A6761

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Presurgical Identification of Primary Central Nervous System Lymphoma with Normalized Time-Intensity Curve: A Pilot Study of a New Method to Analyze DSC-PWI
A. Pons-Escoda, A. Garcia-Ruiz, P. Naval-Baudin, M. Cos, N. Vidal, G. Plans, J. Bruna, R. Perez-Lopez, C. Majos
American Journal of Neuroradiology Oct 2020, 41 (10) 1816-1824; DOI: 10.3174/ajnr.A6761
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Imaging of Lymphomas Involving the CNS: An Update-Review of the Full Spectrum of Disease with an Emphasis on the World Health Organization Classifications of CNS Tumors 2021 and Hematolymphoid Tumors 2022
  • Diffuse Large B-Cell Epstein-Barr Virus-Positive Primary CNS Lymphoma in Non-AIDS Patients: High Diagnostic Accuracy of DSC Perfusion Metrics
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Adult Brain

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • WM Neuroaxonal Loss in Type 1 Diabetes
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire