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Index by author

May 01, 2019; Volume 40,Issue 5

  1. Vadapalli, R.

    1. FELLOWS' JOURNAL CLUBPediatrics
      Focal Cortical Dysplasia and Refractory Epilepsy: Role of Multimodality Imaging and Outcome of Surgery
      S. Jayalakshmi, S.K. Nanda, S. Vooturi, R. Vadapalli, P. Sudhakar, S. Madigubba and M. Panigrahi
      American Journal of Neuroradiology May 2019, 40 (5) 892-898; DOI: https://doi.org/10.3174/ajnr.A6041

      The authors performed a retrospective analysis of data from 188 consecutive patients with focal cortical dysplasia and refractory epilepsy with at least 2 years of postsurgery follow-up. Predictors of seizure freedom and the sensitivity of neuroimaging modalities were analyzed. MR imaging showed clear-cut FCD in 136 (72.3%) patients. Interictal FDG-PET showed focal hypo-/hypermetabolism in 144 (76.6%); in 110 patients in whom ictal SPECT was performed, focal hyperperfusion was noted in 77 (70.3%). Focal resection was the most common surgery performed in 112 (59.6%) patients. Histopathology revealed type I FCD in 102 (54.3%) patients. At last follow-up, 124 (66.0%) were seizure-free. Complete resection of FCD and type II FCD were predictors of seizure freedom. Localization of FCD on either MR imaging or PET or ictal SPECT had the highest sensitivity for seizure freedom at 97.5%. They conclude that during presurgical multimodality evaluation, localization of the extent of the epileptogenic zone in at least 2 imaging modalities helps achieve seizure freedom in about two-thirds of patients with refractory epilepsy due to FCD. FDG-PET is the most sensitive imaging modality for seizure freedom, especially in patients with type I FCD.

  2. Valand, H.A.

    1. Chimeric Antigen Receptor T-Cell Therapy: What the Neuroradiologist Needs to Know
      H.A. Valand, F. Huda and R.K. Tu
      American Journal of Neuroradiology May 2019, 40 (5) 766-768; DOI: https://doi.org/10.3174/ajnr.A6042

  3. Vargas, S.A.

    1. Pediatrics
      Neuroimaging Findings in Moebius Sequence
      D.A. Herrera, N.O. Ruge, M.M. Florez, S.A. Vargas, M. Ochoa-Escudero and M. Castillo
      American Journal of Neuroradiology May 2019, 40 (5) 862-865; DOI: https://doi.org/10.3174/ajnr.A6028

  4. Venneti, S.

    1. FELLOWS' JOURNAL CLUBPediatrics
      Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy
      B. Tamrazi, S. Venneti, A. Margol, D. Hawes, S.Y. Cen, M. Nelson, A. Judkins, J. Biegel and S. Blüml
      American Journal of Neuroradiology May 2019, 40 (5) 872-877; DOI: https://doi.org/10.3174/ajnr.A6024

      Twenty patients with confirmed atypical teratoid/rhabdoid tumors who underwent MR spectroscopy were included in this study. In vivo metabolite levels of atypical teratoid/rhabdoid tumors were compared with molecular subtypes assessed by achaete-scute homolog 1 expression. In vivo creatine concentrations were higher in tumors that demonstrated achaete-scute homolog 1 expression compared with those without achaete-scute homolog 1 expression. Additionally, levels of myo-inositol were significantly different, whereas lipids approached significance in these 2 cohorts. Higher brain-specific creatine kinase levels were observed in the cohort with achaete-scute homolog 1 expression.

  5. Verny, C.

    1. Adult Brain
      GJA1 Variants Cause Spastic Paraplegia Associated with Cerebral Hypomyelination
      L. Saint-Val, T. Courtin, P. Charles, C. Verny, M. Catala, R. Schiffmann, O. Boespflug-Tanguy and F. Mochel
      American Journal of Neuroradiology May 2019, 40 (5) 788-791; DOI: https://doi.org/10.3174/ajnr.A6036

  6. Vooturi, S.

    1. FELLOWS' JOURNAL CLUBPediatrics
      Focal Cortical Dysplasia and Refractory Epilepsy: Role of Multimodality Imaging and Outcome of Surgery
      S. Jayalakshmi, S.K. Nanda, S. Vooturi, R. Vadapalli, P. Sudhakar, S. Madigubba and M. Panigrahi
      American Journal of Neuroradiology May 2019, 40 (5) 892-898; DOI: https://doi.org/10.3174/ajnr.A6041

      The authors performed a retrospective analysis of data from 188 consecutive patients with focal cortical dysplasia and refractory epilepsy with at least 2 years of postsurgery follow-up. Predictors of seizure freedom and the sensitivity of neuroimaging modalities were analyzed. MR imaging showed clear-cut FCD in 136 (72.3%) patients. Interictal FDG-PET showed focal hypo-/hypermetabolism in 144 (76.6%); in 110 patients in whom ictal SPECT was performed, focal hyperperfusion was noted in 77 (70.3%). Focal resection was the most common surgery performed in 112 (59.6%) patients. Histopathology revealed type I FCD in 102 (54.3%) patients. At last follow-up, 124 (66.0%) were seizure-free. Complete resection of FCD and type II FCD were predictors of seizure freedom. Localization of FCD on either MR imaging or PET or ictal SPECT had the highest sensitivity for seizure freedom at 97.5%. They conclude that during presurgical multimodality evaluation, localization of the extent of the epileptogenic zone in at least 2 imaging modalities helps achieve seizure freedom in about two-thirds of patients with refractory epilepsy due to FCD. FDG-PET is the most sensitive imaging modality for seizure freedom, especially in patients with type I FCD.

  7. Vossough, A.

    1. Letter
      Use of Balanced Steady-State Free Precession Sequences in Evaluation of Drop Metastases
      A. Vossough and E.R. Melhem
      American Journal of Neuroradiology May 2019, 40 (5) E20; DOI: https://doi.org/10.3174/ajnr.A5964
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