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Research ArticleAdult Brain
Open Access

Arterial Spin-Labeling Parameters Influence Signal Variability and Estimated Regional Relative Cerebral Blood Flow in Normal Aging and Mild Cognitive Impairment: FAIR versus PICORE Techniques

K.-O. Lövblad, M.-L. Montandon, M. Viallon, C. Rodriguez, S. Toma, X. Golay, P. Giannakopoulos and S. Haller
American Journal of Neuroradiology July 2015, 36 (7) 1231-1236; DOI: https://doi.org/10.3174/ajnr.A4291
K.-O. Lövblad
aFrom the Divisions of Diagnostic and Interventional Neuroradiology (K.-O.L., M.-L.M., M.V., S.H.)
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M.-L. Montandon
aFrom the Divisions of Diagnostic and Interventional Neuroradiology (K.-O.L., M.-L.M., M.V., S.H.)
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M. Viallon
aFrom the Divisions of Diagnostic and Interventional Neuroradiology (K.-O.L., M.-L.M., M.V., S.H.)
cCREATIS (M.V.), UMR CNRS 5220–Institut National de la Santé et de la Recherche Médicale U1044, INSA de Lyon, Université de Lyon, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France
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C. Rodriguez
bPsychiatry (C.R., S.T., P.G.), Geneva University Hospitals, Geneva, Switzerland
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S. Toma
bPsychiatry (C.R., S.T., P.G.), Geneva University Hospitals, Geneva, Switzerland
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X. Golay
dInstitute of Neurology (X.G.), University College London, London, United Kingdom.
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P. Giannakopoulos
bPsychiatry (C.R., S.T., P.G.), Geneva University Hospitals, Geneva, Switzerland
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S. Haller
aFrom the Divisions of Diagnostic and Interventional Neuroradiology (K.-O.L., M.-L.M., M.V., S.H.)
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Abstract

BACKGROUND AND PURPOSE: Arterial spin-labeling is a noninvasive method to map cerebral blood flow, which might be useful for early diagnosis of neurodegenerative diseases. We directly compared 2 arterial spin-labeling techniques in healthy elderly controls and individuals with mild cognitive impairment.

MATERIALS AND METHODS: This prospective study was approved by the local ethics committee and included 198 consecutive healthy controls (mean age, 73.65 ± 4.02 years) and 43 subjects with mild cognitive impairment (mean age, 73.38 ± 5.85 years). Two pulsed arterial spin-labeling sequences were performed at 3T: proximal inversion with a control for off-resonance effects (PICORE) and flow-sensitive alternating inversion recovery technique (FAIR). Relative cerebral blood flow maps were calculated by using commercial software and standard parameters. Data analysis included spatial normalization of gray matter–corrected relative CBF maps, whole-brain average, and voxelwise comparison of both arterial spin-labeling sequences.

RESULTS: Overall, FAIR yielded higher relative CBF values compared with PICORE (controls, 32.7 ± 7.1 versus 30.0 ± 13.1 mL/min/100 g, P = .05; mild cognitive impairment, 29.8 ± 5.4 versus 26.2 ± 8.6 mL/min/100 g, P < .05; all, 32.2 ± 6.8 versus 29.3 ± 12.3 mL/min/100 g, P < .05). FAIR had lower variability (controls, 36.2% versus 68.8%, P < .00001; mild cognitive impairment, 18.9% versus 22.9%, P < .0001; all, 34.4% versus 64.9% P < .00001). The detailed voxelwise analysis revealed a higher signal for FAIR, notably in both convexities, while PICORE had higher signal predominantly in deep cerebral regions.

CONCLUSIONS: Overall, FAIR had higher estimated relative CBF and lower interindividual variability than PICORE. In more detail, there were regional differences between both arterial spin-labeling sequences. In summary, these results highlight the need to calibrate arterial spin-labeling sequences.

ABBREVIATIONS:

ASL
arterial spin-labeling
FAIR
flow-sensitive alternating inversion recovery technique
MCI
mild cognitive impairment
PICORE
proximal inversion with a control for off-resonance effects
rCBF
relative cerebral blood flow
  • © 2015 by American Journal of Neuroradiology

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American Journal of Neuroradiology: 36 (7)
American Journal of Neuroradiology
Vol. 36, Issue 7
1 Jul 2015
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Cite this article
K.-O. Lövblad, M.-L. Montandon, M. Viallon, C. Rodriguez, S. Toma, X. Golay, P. Giannakopoulos, S. Haller
Arterial Spin-Labeling Parameters Influence Signal Variability and Estimated Regional Relative Cerebral Blood Flow in Normal Aging and Mild Cognitive Impairment: FAIR versus PICORE Techniques
American Journal of Neuroradiology Jul 2015, 36 (7) 1231-1236; DOI: 10.3174/ajnr.A4291

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Arterial Spin-Labeling Parameters Influence Signal Variability and Estimated Regional Relative Cerebral Blood Flow in Normal Aging and Mild Cognitive Impairment: FAIR versus PICORE Techniques
K.-O. Lövblad, M.-L. Montandon, M. Viallon, C. Rodriguez, S. Toma, X. Golay, P. Giannakopoulos, S. Haller
American Journal of Neuroradiology Jul 2015, 36 (7) 1231-1236; DOI: 10.3174/ajnr.A4291
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