Additional Value of 3D Rotational Angiography in Angiographically Negative Aneurysmal Subarachnoid Hemorrhage: How Negative Is Negative?

Abstract

BACKGROUND AND PURPOSE: In some patients with nonperimesencephalic nontraumatic subarachnoid hemorrhage (aneurysmal SAH), no aneurysm can be found on digital subtraction angiography (DSA), and repeat DSA is advocated. 3D rotational angiography (3DRA) is considered superior to DSA in the detection of small intracranial aneurysms. In this study, we assessed the additional diagnostic value of 3DRA in detecting DSA-occult aneurysms in 23 patients with aneurysmal SAH.

MATERIALS AND METHODS: Between January 2006 and September 2007, 298 patients with suggested ruptured intracranial aneurysm were referred for DSA, and in 98 patients, DSA was negative. Of these 98 patients, 28 had aneurysmal SAH, and in 23 of these additional 3DRA was performed in the same or in a repeat angiographic procedure.

RESULTS: In 18 of 23 patients (78%), a ruptured small aneurysm was diagnosed on additional 3DRA. The location of 18 aneurysms was the anterior communicating artery (n = 11), the middle cerebral artery (n = 3), the posterior communicating artery (n = 2), the ophthalmic artery (n = 1), and the posterior inferior cerebellar artery (n = 1). Aneurysm size was 3 mm in 4, 2 mm in 9, and 1 mm in 5. Of 18 aneurysms, 9 were treated with coil placement; 7 with surgical clipping; and 2 were not treated.

CONCLUSION: In this study, 18 of 23 (78%) patients with negative findings on DSA had a small ruptured aneurysm when studied with 3DRA. These were most commonly located on the anterior communicating artery.