Morphologic MR imaging characteristics
| BRAF V600E-Mut (n = 11) | BRAF-KIAA Rearrangement (n = 20) | Wild-Type BRAF (n = 8) | NF1 (n = 12) | P Value | |
|---|---|---|---|---|---|
| Location (No.) (%) | |||||
| Cerebral hemisphere | 3 (27.3%) | 3 (15%) | 1 (12.5%) | 1 (8.3%) | .15 |
| Cerebellum | 1 (9.1%) | 7 (35%) | 5 (62.5%) | 2 (16.7%) | |
| Brainstem | 2 (18.2%) | 6 (30%) | 0 (0%) | 2 (16.7%) | |
| Diencephalon | 5 (45.5%) | 4 (20%) | 2 (25%) | 7 (58.3%) | |
| Well-defined margins (yes/no) | 9.1% (1/10) | 45.0% (9/11) | 62.5% (5/3) | 16.6% (2/10) | .03a,b,c |
| Hemorrhagic components or calcifications (yes/no)* | 0% (0/8) | 15.3% (2/11) | 62.5% (5/3) | 0% (0/6) | .005b,c,f |
| Cystic components (yes/no) | 45.4% (5/6) | 60% (12/8) | 87.5% (7/1) | 0% (0/12) | .001c,d,e |
| Contrast enhancement (yes/no) | 81.8% (9/2) | 85% (17/3) | 100% (8/0) | 50% (6/6) | .04c,d |
Note:—Mut indicates mutant. Each superscript letter represents a significant difference between 2 categories.
↵a BRAF V600E-mutant versus BRAF-KIAA rearrangement.
↵b BRAF V600E-mutant versus BRAF wild-type.
↵c BRAF wild-type versus NF1.
↵d BRAF V600E-mutant versus NF1.
↵e BRAF-KIAA rearrangement versus NF1.
↵f BRAF wild-type versus BRAF-KIAA rearrangement.
↵* Evaluated only when SWI/T2* or CT scans were available (n = 35).