Estimates produced by the linear mixed-effects models for fold change and lesion velocity in the full and restricted cohorts
| Fold Change | Lesion Velocity | |||||
|---|---|---|---|---|---|---|
| Estimate | 95% CI | P | Estimate | 95% CI | P | |
| Full cohort | ||||||
| Time | 0.01 | –0.03–0.04 | .768 | 0.00 | –0.00–0.00 | .989 |
| Phenotype (progressive) | –3.00 | –6.94–0.94 | .142 | 0.340 | –0.10–0.77 | .136 |
| Time*phenotype (progressive) | 2.49 | 2.10–2.89 | <.001 | 0.100 | 0.05–0.14 | <.001 |
| Restricted cohort | ||||||
| Time | 0.01 | –0.06–0.08 | .752 | 0.00 | –0.01–0.01 | .899 |
| Phenotype (progressive) | –3.43 | –11.08–4.21 | .386 | 0.15 | –0.47–0.78 | .632 |
| Time*phenotype (progressive) | 2.54 | 2.04–3.04 | <.001 | 0.11 | 0.06–0.15 | <.001 |
Note:—Asterisk indicates the interaction between phenotype and time in the linear mixed effects model.