Summary of the global observations and statistical analyses according to radiologic/clinical settings and regionalized T1-mapping
| Radiologic and Clinical Settings | Regionalized T1 Mapping | Global Observations | Statistical Significance |
|---|---|---|---|
| Clinical onset | SC at C1, Cmax, C7 | T1 values acute > chronic | No |
| Cervical spinal canal stenosis | SC at disc levels | T1 values increase according to the severity of the stenosis (T1grade0 < T1grade1 < T1grade3) | Grades 3/0; 3/1 (considering all subjects)Grades 3/0_HC, 2/0_HC, 1/0_HC, 0/0_HC (differentiating patients and HC grade 0) |
| OSS | Entire cervical SC | Lower T1 values in the mild-stenosis group | Mild-vs-moderate OSS |
| Clinical severity | Entire cervical SC | T1 values increase according to the clinical severity(T1control < T1mild < T1moderate-to-severe) | HC and patients with moderate-to-severe DCM |
| Inverse relationship between global T1 values and preoperative mJOA scores | Yes | ||
| SC at C1, Cmax, C7 | T1 values increase at C1, Cmax, C7 according to the clinical severity | HC and patients with moderate-to-severe DCM (C1, Cmax, and C7)Patients with mild and moderate-to-severe DCM (Cmax)No statistical difference between controls and patients with mild DCM | |
| WM, anterior and intermediate GM at C1, Cmax, C7 | Global T1-value increase at C1, Cmax, C7 in the WM and GM according to the clinical severity | HC and patients with moderate-to-severe DCM (Cmax and C7 in WM and Cmax in GM)Patients with mild and moderate-to-severe DCM (C1 and Cmax in WM, Cmax in GM)No statistical difference between controls and patients with mild DCM |