Intra-arterial chemotherapy for retinoblastoma in infants weighing ≤10 kg (74 treated eyes with 222 IAC sessions)—patient demographics
| Variable | Weight ≤ 10 kg (n = 74 Eyes; 35.7% of 69 Patients) | Weight >10 kg (n = 133 Eyes; 64.2% of 127 Patients) | P Value | Total (n = 207) Eyes (%) of 196 Patients |
|---|---|---|---|---|
| Age at presentation (months) (n = 196), mean (median, range) | 10 (9, 1–33) | 32 (23, 4–387) | .01 | 24 (15, 1–387) |
| Age at time of first IAC (months) (n = 196), mean (median, range) | 11 (10, 3–30) | 35 (25, 4–387) | .01 | 24 (15, 1–387) |
| Weight at first IAC (kg) (n = 196), mean (median, range) | 8.4 (8.9, 3.1–10.4) | 16.4 (13.3, 10.3–209) | .01 | 13.5 (11.5, 3.1–209) |
| Sex (n = 196) | ||||
| Male | 36 (52.2) | 68 (53.5) | .85 | 104 (53.1) |
| Female | 33 (47.8) | 59 (46.5) | 92 (47.8) | |
| Race (n = 196) | ||||
| White | 37 (53.6) | 59 (46.5) | .31 | 96 (49.0) |
| Asian | 12 (17.4) | 26 (20.5) | 38 (19.4) | |
| African American | 11 (16.0) | 21 (16.5) | 32 (16.3) | |
| Hispanic | 9 (13.0) | 12 (9.4) | 21 (10.7) | |
| Other | 0 | 9 (7.1) | 9 (4.6) | |
| Family history (n = 196) | 4 (5.8) | 8 (6.2) | .88 | 12 (6.1) |
| Genetics (n = 196) | ||||
| Somatic | 31 (44.9) | 51 (40.2) | .29 | 82 (41.8) |
| Germline | 20 (28.9) | 38 (29.9) | 58 (29.6) | |
| 13q deletion syndrome | 2 (2.9) | 0 (0.0) | 2 (1.0) | |
| Unavailable | 16 (23.2) | 38 (29.9) | 54 (27.6) | |
| Laterality of disease (n = 196) | ||||
| Unilateral | 55 (79.7) | 91 (71.7) | .21 | 146 (74.5) |
| Bilateral | 14 (20.3) | 36 (28.3) | 50 (25.5) | |
| Involved eye (n = 196) | ||||
| Right eye | 31 (41.9) | 66 (49.6) | .19 | 97 (49.5) |
| Left eye | 43 (58.1) | 67 (50.4) | 110 (56.1) |