Predictors of neurocognitive domain scores in total groups of patients with MSa
| Standardized Coefficients β | Comparing with the Reference Modelb (G2) (P Value) | ||
|---|---|---|---|
| β (95% CI) | Significance | ||
| Processing (R2 = 43.6%) | 20.9 (<.0001) | ||
| NAWM volume | 0.298 (0.047–0.616) | .0229 | |
| λ | 0.548 (0.236–0.895) | .0011 | |
| Learning (R2 = 40.4%) | 26.1 (<.0001) | ||
| Education | 0.205 (0.022–0.388) | .0283 | |
| T1 lesion loads (log) | −0.300 (−0.581 to −0.019) | .0369 | |
| λ | 0.622 (0.332–0.913) | <.0001 | |
| Executive functioning (R2 = 41.0%) | 4.4 (.1108) | ||
| Education | 0.354 (0.170–0.539) | .0003 | |
| NAWM volume | 0.274 (0.020–0.527) | .0348 | |
| Degree | 0.313 (0.095–0.531) | .0055 | |
| Visual (R2 = 27.5%) | 9.2 (.0024) | ||
| Sex (M/F) | 0.293 (0.056–0.530) | .0160 | |
| T2 lesion loads (log) | 0.367 (0.204–0.714) | .0383 | |
| Density (%) | 0.523 (0.236–0.809) | .0005 | |
| Language (R2 = 35.8%) | 7.9 (.0953) | ||
| EDSS (log) | −0.376 (−0.648 to −0.104) | .0074 | |
| Disease duration (log) | 0.224 (0.007–0.441) | .0433 | |
| NAWM volume | 0.318 (0.037–0.600) | .0274 | |
| Degree | −0.254 (−0.486 to −0.021) | .0330 | |
| Average score (R2 = 56.2%) | 21.3 (<.0001) | ||
| Education | 0.305 (0.139–0.471) | .0005 | |
| T1 lesion loads (log) | −0.261 (−0.515 to −0.008) | .0434 | |
| NAWM volume | 0.343 (0.109–0.576) | .0046 | |
| λ | 0.404 (0.12–0.696) | .0073 | |
↵a Backward stepwise elimination multivariable regression was conducted after accounting for sex, education, global gray matter volume, and T1 and T2 lesion loads (log). The Table shows the best regression model for each dependent variable (neurocognitive domain scores).
↵b Reference model included only confounding factors of sex, education, global gray matter volume, and T1 and T2 lesion loads (log). The G2 likelihood ratio test was used to compare the best regression model with the reference model. P < .05 was considered statistically significant.