Demographics and clinical information

Whole SampleHealthy Controls (n = 80)EMCI (n = 79)LMCI (n = 77)AD (n = 79)P
Age (mean) (yr)75.2 ± 6.470.2 ± 7.772.3 ± 7.275.0 ± 7.5<.001a
Female (No.) (%)41 (51.3)36 (45.6)32 (41.6)36 (45.6).680
Education (mean) (yr)16.4 ± 2.315.9 ± 2.716.5 ± 2.715.3 ± 3.1.022a
ADAS-cog score (mean)9.7 ± 4.311.9 ± 5.418.3 ± 6.230.4 ± 6.9<.001a
CSF amyloid subsample(n = 53)(n = 68)(n = 54)(n = 47)
 CSF Aβ-42 (ng/L) (mean)192.5 ± 56.3193.5 ± 50166.6 ± 52.3137.4 ± 32<.001a
 Positive CSF Aβ-42 status (No.) (%)26 (49.1)25 (36.8)36 (66.7)45 (95.7)<.001a
CSF tau subsample(n = 31)(n = 68)(n = 48)(n = 20)
 CSF P-tau (pg/mL) (mean)38.9 ± 28.835.1 ± 21.744.1 ± 21.058.1 ± 26.2.002a
 Positive CSF P-tau status (No.) (%)22 (71.0)42 (61.8)41 (85.4)19 (95.0).004a
APOE subsample(n = 78)(n = 75)(n = 74)(n = 77)
APOE-4 carriers (No.) (%)25 (32.1)31 (41.3)37 (50.0)50 (64.9)<.001a
  • a Significant.