Table 3:

Independent predictors of EGFR mutation status

PredictorsEGFR Mutation (Exon 19 + 20 + 21)EGFR Mutation (Exon 19 + 21)
OR (95% CI)P ValueOR (95% CI)P Value
Female sex1.630 (0.539–4.927).3871.538 (0.483–4.898).466
Age, per 1-yr increase0.975 (0.928–1.024).3070.972 (0.923–1.024).282
Site of BM
    Anterior circulation–dominantaReferenceReference
    Posterior circulation–dominantb0.750 (0.132–4.250).7450.833 (0.145–4.781).837
    Even distribution0.867 (0.275–2.734).8070.741 (0.222–2.471).625
No. of BM
    1ReferenceReference
    1<BM<101.765 (0.491–6.337).3831.765 (0.446–6.979).418
    ≥106.000 (0.873–41.214).0687.500 (1.039–54.116).045
Target lesion size of BM
     <10 mmReferenceReference
    10 mm≤BM<30 mm1.015 (0.318–3.243).9790.923 (0.275–3.102).897
    ≥30 mm1.500 (0.315–7.135).611.333 (0.260–6.828).729
Intratumoral necrosis1.188 (0.395–3.569).7590.887 (0.273–2.884).841
Intratumoral hemorrhage1.440 (0.382–5.428).591.412 (0.353–5.649).625
Diffusion visual scoring1.630 (0.680–2.601).1991.514 (0.722–2.974).274
ADCmin0.996 (0.992–1.000).0280.995 (0.991–0.999).020
nADC ratio0.064 (0.006–0.666).0210.044 (0.004–0.563).016
  • a BMs mainly located in the frontal, parietal, and temporal lobes.

  • b BMs mainly located in the occipital lobes, cerebellum, and brain stem.