Sensitivity, specificity, positive/negative predictive values, and positive/negative likelihood ratios of the MR imaging bright spot sign in healthy subjects and patients with GCA-AION or NA-AION
| No. of Participants | TP Results | TN Results | FP Results | FN Results | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | PLR | NLR | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NA-AION vs GCA-AION | |||||||||||
| Observer 1 | 30 | 15 | 8 | 7 | 0 | 100 | 53.3 | 68.2 | 100 | 2.1 | 0 |
| Observer 2 | 30 | 15 | 9 | 6 | 0 | 100 | 60 | 71.4 | 100 | 3.5 | 0 |
| Observer 3 | 30 | 15 | 9 | 6 | 0 | 100 | 60 | 71.4 | 100 | 3.5 | 0 |
| NA-AION vs healthy subjects | |||||||||||
| Observer 1 | 30 | 7 | 15 | 0 | 8 | 46.7 | 100 | 100 | 65.2 | 0.5 | |
| Observer 2 | 30 | 6 | 15 | 0 | 9 | 40 | 100 | 100 | 62.5 | 0.6 | |
| Observer 3 | 30 | 6 | 15 | 0 | 9 | 40 | 100 | 100 | 62.5 | 0.6 | |
| GCA-AION vs healthy subjects | |||||||||||
| Observer 1 | 30 | 15 | 15 | 0 | 0 | 100 | 100 | 100 | 100 | 0 | |
| Observer 2 | 30 | 15 | 15 | 0 | 0 | 100 | 100 | 100 | 100 | 0 | |
| Observer 3 | 30 | 15 | 15 | 0 | 0 | 100 | 100 | 100 | 100 | 0 |
Note:—FN indicates false-negative; FP, false-positive; PLR, positive likelihood ratio; NLR, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; TN, true-negative; TP, true-positive.