Table 2:

Comparison of neuropsychological measures between patients with Parkinson disease with and without mild cognitive impairment

Neuropsychological MeasuresPD-NCI (Mean) (SD)PD-MCI (Mean) (SD)Adjusted P Value
Global cognition (mean) (SD)
    MMSE28.4 (1.6)26.7 (2.6).016a,b
    MOCA27.0 (2.9)24.5 (2.4).018a,b
    ADAS116.8 (4.2)9.8 (3.5).071a,b
    Global Index0.1 (0.5)−0.3 (0.3).008a,b
Cognitive tests (mean) (SD)
    Clock drawing9.31 (1.25)8.48 (1.47).126
    Frontal Assessment Battery16.69 (1.38)15.28 (2.09).027
    Digit Span17.42 (3.50)15.04 (2.24).015
    Digit Cancellation19.86 (6.54)15.08 (6.45).063
    Color Trail 180.48 (37.59)137.24 (82.08).008
    Color Trail 2138.94 (60.75)229.58 (103.31).002
    Maze18.63 (10.59)30.80 (17.83).005
    Maze errors0.06 (0.30)0.04 (0.20).942
    ADAS: Immediate and Delayed Recall5.08 (2.69)7.04 (3.28).090
    ADAS: Recognition1.55 (2.22)2.00 (2.50).644
    ADAS: Language1.15 (1.37)2.00 (1.71).168
    Fruit Fluency14.11 (3.29)11.24 (2.80).029
Cognitive domains (mean) (SD)
    Executive function0.4 (1.5)−1.0 (2.0).023a,b
    Attention/working memory0.8 (1.7)−2.0 (2.4)<.000a,b
    Visuospatial0.0 (1.8)−0.1 (1.4).919d
    Episodic memory0.3 (1.6)−0.6 (1.5).193b
    Language0.4 (1.4)−1.0 (1.5).018a,b
  • Note:—MMSE indicates Mini-Mental State Examination; MOCA, Montreal Cognitive Assessment; ADAS11, Alzheimer Disease Assessment Scale-Cognitive.

  • a Significant differences at P < .05 level.

  • b Analysis of covariance test, corrected for age, sex, and education.